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Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus

Authors
 Jungsoo Lee  ;  Jung U Shin  ;  Seongmin Noh  ;  Chang Ook Park  ;  Kwang Hoon Lee 
Citation
 ANNALS OF DERMATOLOGY, Vol.28(2) : 159-163, 2016 
Journal Title
 ANNALS OF DERMATOLOGY 
ISSN
 1013-9087 
Issue Date
2016
Keywords
Elderly ; Naltrexone ; Pruritus
Abstract
BACKGROUND: Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. OBJECTIVE: We evaluated the efficacy and safety of naltrexone (Revia®), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics. METHODS: Eighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months. RESULTS: Using the visual analogue scale, 13 (72.2%) of 18 patients showed a "much improved" condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed. CONCLUSION: Naltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients.
Files in This Item:
T201601325.pdf Download
DOI
10.5021/ad.2016.28.2.159
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Kwang Hoon(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146798
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