404 386

Cited 14 times in

Use of Wisteria Floribunda Agglutinin-Positive Human Mac-2 Binding Protein in Assessing Risk of Hepatocellular Carcinoma Due to Hepatitis B Virus.

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author안성수-
dc.contributor.author한광협-
dc.contributor.author허자윤-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author김현숙-
dc.contributor.author박영년-
dc.date.accessioned2017-02-24T11:20:20Z-
dc.date.available2017-02-24T11:20:20Z-
dc.date.issued2016-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146739-
dc.description.abstractWisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA-M2BP) is a serologic marker corresponding with degree of hepatic fibrosis. We evaluated its accuracy in assessing hepatic fibrosis and in predicting the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).In a 5-year period (2009-2013), a total of 95 CHB patients with available serum WFA-M2BP assay and transient elastography assessment [to assess liver stiffness (LS)] who had undergone liver biopsy were recruited for retrospective analysis.Areas under the receiver operating characteristic curve for predicting fibrosis stages via serum WFA-M2BP level were as follows: ≥F2, 0.688; ≥F3, 0.694; and F4, 0.704 (all P < 0.05). During the follow-up period (median, 45 months), HCC developed in 7 patients (7.4%). In patients with HCC, age, use of antiviral therapy, test parameters (HBV DNA, WFA-M2BP, and LS determinations), and histologic stage of fibrosis were all significantly greater than in those free of HCC, whereas platelet count was significantly lower (all P < 0.05). On multivariate analysis, WFA-M2BP was found independently predictive of emergent HCC [hazard ratio (HR) = 2.375; P = 0.036], although LS and histologic stage of fibrosis were not (P > 0.05). Risk of developing HCC was significantly greater in patients with high WFA-M2BP levels (≥1.8) (adjusted HR = 11.5; P = 0.025). Cumulative incidence rates of HCC were also significantly higher in patients with high (vs. low) levels of WFA-M2BP (log-rank test, P = 0.016).WFA-M2BP determination significantly reflected degree/extent of hepatic fibrosis and independently predicted the risk of developing HCC in patients with CHB.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntigens, Neoplasm/blood*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCarcinoma, Hepatocellular/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/epidemiology-
dc.subject.MESHCarcinoma, Hepatocellular/virology*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/blood*-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/blood*-
dc.subject.MESHLiver Neoplasms/epidemiology-
dc.subject.MESHLiver Neoplasms/virology*-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/blood*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlant Lectins/blood*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHReceptors, N-Acetylglucosamine/blood*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment/methods-
dc.titleUse of Wisteria Floribunda Agglutinin-Positive Human Mac-2 Binding Protein in Assessing Risk of Hepatocellular Carcinoma Due to Hepatitis B Virus.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJa Yoon Heo-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorHyon-Suk Kim-
dc.identifier.doi10.1097/MD.0000000000003328-
dc.contributor.localIdA00385-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA04268-
dc.contributor.localIdA04702-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01117-
dc.contributor.localIdA01563-
dc.contributor.localIdA02233-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid27057911-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameAn, Sung Su-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameHeo, Ja Yoon-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorHeo, Ja Yoon-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.citation.volume95-
dc.citation.number14-
dc.citation.startPagee3328-
dc.identifier.bibliographicCitationMEDICINE, Vol.95(14) : e3328, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.