313 241

Cited 20 times in

Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore

Authors
 D. Torumkuney  ;  R. Chaiwarith  ;  W. Reechaipichitkul  ;  K. Malatham  ;  V. Chareonphaibul  ;  C. Rodrigues  ;  D. S. Chitins  ;  M. Dias  ;  S. Anandan  ;  S. Kanakapura  ;  Y. J. Park  ;  K. Lee  ;  H. Lee  ;  J. Y. Kim  ;  Y. Lee  ;  H. K. Lee  ;  J. H. Kim  ;  T. Y. Tan  ;  Y. X. Heng  ;  P. Mukherjee  ;  I. Morrissey 
Citation
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.7(Suppl 1) : 3-19, 2016 
Journal Title
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
ISSN
 0305-7453 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology* ; Asia, Southeastern/epidemiology ; Child ; Child, Preschool ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/microbiology* ; Drug Resistance, Bacterial* ; Epidemiological Monitoring ; Haemophilus influenzae/drug effects* ; Haemophilus influenzae/isolation & purification ; Humans ; India/epidemiology ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Moraxella (Branhamella) catarrhalis/drug effects* ; Moraxella (Branhamella) catarrhalis/isolation & purification ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/microbiology* ; Streptococcus/classification ; Streptococcus/drug effects* ; Streptococcus/isolation & purification ; Young Adult
Abstract
OBJECTIVES: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. METHODS: MICs were determined using Etest(®) for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. RESULTS: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from 21.2% in South Korea to 63.8% in Singapore. In contrast, susceptibility using CLSI intravenous breakpoints was much higher, at 79% in South Korea and ∼95% or higher elsewhere. Macrolide susceptibility was ∼20% in South Korea and ∼50%-60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (∼20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of β-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%). CONCLUSIONS: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCAST showing lower susceptibility. There was considerable variability in susceptibility among countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.
Files in This Item:
T201601102.pdf Download
DOI
10.1093/jac/dkw073
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146693
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links