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Natural killer cells in hepatitis C: Current progress

DC FieldValueLanguage
dc.contributor.author이재면-
dc.date.accessioned2017-02-24T11:12:05Z-
dc.date.available2017-02-24T11:12:05Z-
dc.date.issued2016-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146685-
dc.description.abstractPatients infected with the hepatitis C virus (HCV) are characterized by a high incidence of chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The functional impairment of HCV-specific T cells is associated with the evolution of an acute infection to chronic hepatitis. While T cells are the important effector cells in adaptive immunity, natural killer (NK) cells are the critical effector cells in innate immunity to virus infections. The findings of recent studies on NK cells in hepatitis C suggest that NK cell responses are indeed important in each phase of HCV infection. In the early phase, NK cells are involved in protective immunity to HCV. The immune evasion strategies used by HCV may target NK cells and might contribute to the progression to chronic hepatitis C. NK cells may control HCV replication and modulate hepatic fibrosis in the chronic phase. Further investigations are, however, needed, because a considerable number of studies observed functional impairment of NK cells in chronic HCV infection. Interestingly, the enhanced NK cell responses during interferon-α-based therapy of chronic hepatitis C indicate successful treatment. In spite of the advances in research on NK cells in hepatitis C, establishment of more physiological HCV infection model systems is needed to settle unsolved controversies over the role and functional status of NK cells in HCV infection.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1449~1460-
dc.languageEnglish-
dc.publisherBaishideng Publishing Group-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntiviral Agents/therapeutic use-
dc.subject.MESHCoinfection-
dc.subject.MESHDisease Progression-
dc.subject.MESHHIV Infections/immunology-
dc.subject.MESHHIV Infections/virology-
dc.subject.MESHHepacivirus/drug effects-
dc.subject.MESHHepacivirus/immunology*-
dc.subject.MESHHepacivirus/pathogenicity-
dc.subject.MESHHepatitis C, Chronic/drug therapy-
dc.subject.MESHHepatitis C, Chronic/immunology*-
dc.subject.MESHHepatitis C, Chronic/virology-
dc.subject.MESHHost-Pathogen Interactions-
dc.subject.MESHHumans-
dc.subject.MESHKiller Cells, Natural/drug effects-
dc.subject.MESHKiller Cells, Natural/immunology*-
dc.subject.MESHKiller Cells, Natural/virology-
dc.subject.MESHPhenotype-
dc.subject.MESHTreatment Outcome-
dc.titleNatural killer cells in hepatitis C: Current progress-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Microbiology-
dc.contributor.googleauthorJoo Chun Yoon-
dc.contributor.googleauthorChang Mo Yang-
dc.contributor.googleauthorYoukyong Song-
dc.contributor.googleauthorJae Myun Lee-
dc.identifier.doi10.3748/wjg.v22.i4.1449-
dc.contributor.localIdA03071-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid26819513-
dc.subject.keywordAccessory cell-
dc.subject.keywordAcute hepatitis-
dc.subject.keywordChronic hepatitis-
dc.subject.keywordHepatitis C virus-
dc.subject.keywordImmune evasion-
dc.subject.keywordNatural killer cell-
dc.subject.keywordTreatment response-
dc.subject.keywordVirus-host interaction-
dc.contributor.alternativeNameLee, Jae Myun-
dc.contributor.affiliatedAuthorLee, Jae Myun-
dc.citation.volume22-
dc.citation.number4-
dc.citation.startPage1449-
dc.citation.endPage1460-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.22(4) : 1449-1460, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47430-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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