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자가항체 양성인 Ketosis-Prone 당뇨병 1예

Other Titles
 A Case of Autoantibody-Positive Ketosis-Prone Diabetes Mellitus 
Authors
 윤보라  ;  김규리  ;  배재현  ;  윤유정  ;  이용호  ;  이병완  ;  안철우  ;  차봉수  ;  이현철  ;  강은석 
Citation
 Journal of Korean Diabetes, Vol.17(1) : 60-66, 2016 
Journal Title
 Journal of Korean Diabetes 
ISSN
 2233-7431 
Issue Date
2016
Keywords
Diabetic ketoacidosis ; Type 2 diabetes mellitus
Abstract
Ketosis-prone diabetes mellitus (KPD), which is an atypical type of diabetic mellitus with severe β cell dysfunction, is accompanied by ketosis or ketoacidosis without specific preceding factors at diagnosis. KPD shows mixed features of type 1 and type 2 diabetes. In some cases, the recovery of the function of β cells during intensified diabetic management enabled the termination of insulin therapy. The Aβ classification system classifies KPD patients into four distinct subgroups depending upon the presence or absence of β cell autoimmunity and β cell functional reserve and has been recognized as an important tool to predict clinical outcomes. In Korea, several cases of KPD with absence of β cell autoimmunity have been reported. A 60-year-old man presenting with DKA (diabetic ketoacidosis) as the first manifestation of diabetes, was shown to have β cell autoimmunity. A significant improvement in glycemic control was shown as a result of aggressive diabetic management; shortly after an acute episode of DKA, the recovery of β cell functional reserve was confirmed. This result allowed discontinuation of insulin therapy and maintenance of euglycemic status without antidiabetic medication.
Files in This Item:
T201601045.pdf Download
DOI
10.4093/jkd.2016.17.1.60
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김규리(Kim, Gyuri)
배재현(Bae, Jae Hyun) ORCID logo https://orcid.org/0000-0002-3462-890X
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
윤보라(Yoon, Bo Ra)
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
이현철(Lee, Hyun Chul)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146659
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