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Non-Paraneoplastic Autoimmune Retinopathy: The First Case Report in Korea

DC Field Value Language
dc.contributor.author고형준-
dc.contributor.author김민-
dc.contributor.author이성철-
dc.contributor.author최은영-
dc.contributor.author최은영-
dc.contributor.author김다희-
dc.date.accessioned2017-02-24T08:16:07Z-
dc.date.available2017-02-24T08:16:07Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146606-
dc.description.abstractAutoimmune retinopathy (AIR) is an immune-mediated retinopathy, resulting from an immunologic process caused by the aberrant recognition of retinal antigens as autoantigens. The diagnosis of AIR involves the detection of antiretinal antibodies with concurrent clinical and electrophysiological evidence of retinopathy. A 40-year-old patient presented with progressive loss of bilateral vision over several months. A fundus examination was unremarkable. Spectral domain optical coherence tomography revealed a blurred photoreceptor ellipsoid zone at the subfoveal region in both eyes with more prominent disruption in the left eye. Full-field electroretinography (ERG) showed relatively normal rod and cone responses in the right eye, and decreased photopic bwaves with minimal attenuation of a-waves in the left eye. Multifocal ERG demonstrated slightly reduced amplitude of the inner segment ring in the right eye and decreased amplitudes and delayed latencies of all modalities in the left eye. The patient was suspected to have AIR and it was supported by positive Western blots for 23-kDa protein, enolase (46-kDa), aldolase (40-kDa), 62-kDa and 78-kDa proteins and by immunohistochemical staining of human retinal bipolar and ganglion cells. Despite the immunosuppressive treatment, the destruction of the retinal photoreceptors progressed, and immunosuppressive interventions produced very little visual improvement. We report on what is, to the best of our knowledge, the very first case of serologically confirmed nonparaneoplastic AIR in Korea.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAutoantibodies/blood*-
dc.subject.MESHAutoantibodies/immunology-
dc.subject.MESHAutoantigens-
dc.subject.MESHAutoimmune Diseases/immunology*-
dc.subject.MESHElectroretinography-
dc.subject.MESHHumans-
dc.subject.MESHImmunologic Factors-
dc.subject.MESHParaneoplastic Syndromes/immunology*-
dc.subject.MESHParaneoplastic Syndromes, Ocular-
dc.subject.MESHPhosphopyruvate Hydratase-
dc.subject.MESHRecoverin-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetina/immunology*-
dc.subject.MESHRetinal Diseases/immunology*-
dc.subject.MESHTomography, Optical Coherence-
dc.titleNon-Paraneoplastic Autoimmune Retinopathy: The First Case Report in Korea-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorEun Young Choi-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorGrazyna Adamus-
dc.contributor.googleauthorHyoung Jun Koh-
dc.contributor.googleauthorSung Chul Lee-
dc.identifier.doi10.3349/ymj.2016.57.2.527-
dc.contributor.localIdA00152-
dc.contributor.localIdA00455-
dc.contributor.localIdA02873-
dc.contributor.localIdA04831-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26847311-
dc.subject.keywordAIR-
dc.subject.keywordAutoimmune retinopathy-
dc.subject.keywordantiretinal antibodies-
dc.subject.keywordenolase-
dc.subject.keywordnonparaneoplastic autoimmune retinopathy-
dc.subject.keywordrecoverin-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameKim, Min-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameChoi, Eun Young-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorKim, Min-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorKim, Da Hee-
dc.citation.volume57-
dc.citation.number2-
dc.citation.startPage527-
dc.citation.endPage531-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(2) : 527-531, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46415-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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