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Glucocorticoid-mediated anti-inflammatory effect through NFκB is preserved in the absence of Dexras1

Authors
 Ji Hyun Yong  ;  Jo Woon Seok  ;  Jung Hwan Yu  ;  Yoonjeong Choi  ;  Su Jin Song  ;  Ara Kim  ;  Hyo Jung Kim  ;  Jae-woo Kim 
Citation
 Animal Cells and Systems, Vol.20(1) : 1-6, 2016 
Journal Title
 Animal Cells and Systems 
ISSN
 1976-8354 
Issue Date
2016
Keywords
Dexras1 ; glucocorticoid ; anti-inflammatory effects ; dexamethasone ; NFκB ; IL-6
Abstract
Glucocorticoids effectively mediate the resolution of inflammation, but long-term use of glucocorticoids inevitably causes metabolic side effects. However, it is unknown if metabolic effectors such as Dexras1, a dexamethasone-stimulated protein, play a role in the anti-inflammatory outcome of dexamethasone. Here, we demonstrate that Dexras1 is required for the dexamethasone-induced upregulation of annexin A1 expression, but is not involved in the reduction of inflammation as evidenced by decreased pro-inflammatory parameters. In the absence of Dexras1, lipopolysaccharide (LPS)-induced interleukin-6 expression was suppressed when murine macrophage RAW264.7 cells were treated with dexamethasone. Similar observations were made in the blood of Dexras1 knockout mice. Furthermore, dexamethasone suppressed the LPS-stimulated increase of NFκB-p65 in both control and Dexras1-absent RAW264.7 cells. Interestingly, depletion of Dexras1 resulted in the loss of pERK production. These results suggest that Dexras1 is involved primarily in the metabolic side effects and its inhibition preserves the anti-inflammatory action of glucocorticoids. Thus, the inhibition of Dexras1 will be an excellent target for reducing steroid-induced side effects.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/19768354.2016.1140676?journalCode=tacs20
DOI
10.1080/19768354.2016.1140676
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
김재우(Kim, Jae Woo) ORCID logo https://orcid.org/0000-0001-5456-9495
김효정(Kim, Hyo Jung) ORCID logo https://orcid.org/0000-0002-3514-1247
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146604
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