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Prevalence and treatment pattern of Parkinson's disease dementia in Korea

Authors
 Yoon-Sang Oh  ;  Joong-Seok Kim  ;  In-Seok Park  ;  Yong-Soo Shim  ;  In-Uk Song  ;  Jeong-Wook Park  ;  Phil-Hyu Lee  ;  Chul-Hyung Lyoo  ;  Tae-Beom Ahn  ;  Hyo-Il Ma  ;  Yong-Duk Kim  ;  Seong-Beom Koh  ;  Seung-Jae Lee  ;  Kwang-Soo Lee 
Citation
 Geriatrics & Gerontology International, Vol.16(2) : 230-236, 2016 
Journal Title
 Geriatrics & Gerontology International 
ISSN
 1444-1586 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Cognitive Dysfunction/epidemiology* ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy* ; Dementia/epidemiology* ; Dementia/etiology ; Dementia/therapy* ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications* ; Prevalence ; Republic of Korea/epidemiology
Keywords
Parkinson's disease ; cognitive impairment ; dementia ; prevalence ; treatment
Abstract
AIM: The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). METHODS: A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. RESULTS: Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used. CONCLUSION: The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ggi.12457/abstract
DOI
10.1111/ggi.12457
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146591
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