Cited 4 times in
P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2017-02-24T08:13:48Z | - |
dc.date.available | 2017-02-24T08:13:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1536-1632 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146590 | - |
dc.description.abstract | PURPOSE: The aim of this study was to determine whether the brain uptake of [(18)F]Mefway is influenced by the action of P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) in rodents. PROCEDURES: [(18)F]Mefway was applied to rats pharmacologically inhibited with tariquidar (TQD) and to genetically disrupted mice. RESULTS: Pretreatment of TQD results in 160% higher hippocampal uptake compared with control rats. In genetically disrupted mice, a maximal brain uptake value of 3.2 SUV in the triple knockout mice (tKO, Mdr1a/b((-/-))Bcrp1((-/-))) was comparable to that of the double knockout mice (dKO, Mdr1a/b((-/-))) and 2-fold those of the wild-type and Bcrp1((-/-)) knockout mice. The differences of binding values were statistically insignificant between control and experimental groups. The brain-to-plasma ratios for tKO mice were also two to five times higher than those for other groups. CONCLUSIONS: [(18)F]Mefway is modulated by P-gp, and not by Bcrp in rodents. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | MOLECULAR IMAGING AND BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Sub-Family G, Member 2/metabolism* | - |
dc.subject.MESH | ATP-Binding Cassette, Sub-Family B, Member 1/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Fluorine Radioisotopes/pharmacokinetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Piperazines/blood | - |
dc.subject.MESH | Piperazines/pharmacokinetics* | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Pyridines/blood | - |
dc.subject.MESH | Pyridines/pharmacokinetics* | - |
dc.subject.MESH | Quinolines/administration & dosage | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pharmacology | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Jin Sook Song | - |
dc.contributor.googleauthor | Minkyung Lee | - |
dc.contributor.googleauthor | Woon-Ki Cho | - |
dc.contributor.googleauthor | Jin Chung | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Jiae Park | - |
dc.contributor.googleauthor | Kyo Chul Lee | - |
dc.contributor.googleauthor | Kyeong Min Kim | - |
dc.contributor.googleauthor | Jee Hae Kang | - |
dc.contributor.googleauthor | Myung Ae Bae | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.identifier.doi | 10.1007/s11307-015-0883-z | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A04695 | - |
dc.relation.journalcode | J02887 | - |
dc.identifier.eissn | 1860-2002 | - |
dc.identifier.pmid | 26250653 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s11307-015-0883-z | - |
dc.subject.keyword | Breast cancer resistance protein | - |
dc.subject.keyword | P-glycoprotein | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | [18F]Mefway | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Choi, Jae Yong | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Jae Yong | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 267 | - |
dc.citation.endPage | 273 | - |
dc.identifier.bibliographicCitation | MOLECULAR IMAGING AND BIOLOGY, Vol.18(2) : 267-273, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46399 | - |
dc.type.rims | ART | - |
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