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Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Authors
 Jae-Hoon Lee  ;  Young Hoon Ryu  ;  Chul Hyoung Lyoo  ;  Soo-Hee Choi  ;  Jae-Jin Kim  ;  Jae Yong Choi 
Citation
 Applied Radiation and Isotopes, Vol.107 : 127-132, 2016 
Journal Title
 Applied Radiation and Isotopes 
ISSN
 0969-8043 
Issue Date
2016
MeSH
Adult ; Fluorine Radioisotopes*/pharmacokinetics ; Humans ; Male ; Multimodal Imaging ; Piperazines*/pharmacokinetics ; Positron-Emission Tomography/methods* ; Positron-Emission Tomography/statistics & numerical data ; Pyridines*/pharmacokinetics ; Radiopharmaceuticals*/pharmacokinetics ; Receptor, Serotonin, 5-HT1A/metabolism* ; Reference Values ; Tomography, X-Ray Computed ; Young Adult
Keywords
Optimal acquisition time ; Positron emission tomography ; Serotonin 1A receptor ; Standardized uptake value ratio ; [(18)F]Mefway
Abstract
To determine the optimal acquisition time of [(18)F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40 min and there was a strong correlation between DVR and SUVR in the 60-80 min. Therefore, we recommend the use of a single time point between 60 and 80 min for [(18)F]Mefway static PET.
Full Text
http://www.sciencedirect.com/science/article/pii/S0969804315302049
DOI
10.1016/j.apradiso.2015.10.004
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
류철형(Lyoo, Chul Hyoung)
유영훈(Ryu, Young Hoon)
이재훈(Lee, Jae Hoon)
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146535
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