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Influence of shear stress on erythrocyte aggregation

Authors
 Jeong-Ho Kim  ;  Hoyoon Lee  ;  Byoung-kwon Lee  ;  Sehyun Shin 
Citation
 CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, Vol.62(2) : 165-171, 2016 
Journal Title
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
ISSN
 1386-0291 
Issue Date
2016
MeSH
Blood Platelets/physiology* ; Erythrocyte Aggregation/physiology* ; Erythrocytes/cytology* ; Hemorheology* ; Humans ; Platelet Activation ; Platelet Aggregation ; Pressure ; Rotation ; Shear Strength ; Stress, Mechanical
Keywords
RBC ; aggregation ; platelet aggregation ; shear stress
Abstract
Shear stress is known to induce platelet activation and aggregation. The red blood cell (RBC) aggregation test requires the application of shear stress for the cells to disaggregate for initialization. We tested the hypothesis that applying shear stress may activate platelets, which can influence RBC aggregation. The present study used a commercial microchip-based aggregometer (RheoSCan-AnD300) with a rotating stirrer for RBC disaggregation. Whole blood samples were exposed to different magnitudes of shear stress with various shearing times. As the rotational speed was increased up to 2800 rpm, the RBC aggregation index (AI) of the whole blood increased by up to 30% (p <  0.05), whereas that of the platelet-excluded blood samples did not show any apparent alteration. The AI also increased in proportion with the stirring time. The data suggest that high shear stress affects RBC aggregation through shear-induced platelet aggregation.
Full Text
http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1969
DOI
10.3233/CH-151969
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146516
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