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Emergent Synapse Organizers: LAR-RPTPs and Their Companions

Authors
 K.A. Han  ;  S. Jeon  ;  J.W. Um  ;  J. Ko 
Citation
 INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, Vol.324 : 39-65, 2016 
Journal Title
 INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY 
ISSN
 1937-6448 
Issue Date
2016
MeSH
Animals ; Extracellular Space/metabolism ; Humans ; Intracellular Space/metabolism ; Models, Biological ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/chemistry ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/metabolism* ; Signal Transduction ; Synapses/metabolism*
Keywords
LAR ; PTPδ ; PTPσ ; alternative splicing ; heparan sulfate ; ligands ; receptor protein tyrosine phosphatase ; synapse development ; synaptic adhesion
Abstract
Leukocyte common antigen-related receptor tyrosine phosphatases (LAR-RPTPs) have emerged as key players that organize various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. Recent research has highlighted the roles of LAR-RPTPs at neuronal synapses in mediating distinct synaptic adhesion pathways through interactions with a host of extracellular ligands and in governing a variety of intracellular signaling cascades through binding to various scaffolds and signaling proteins. In this chapter, we review and update current research progress on the extracellular ligands of LAR-RPTPs, regulation of their extracellular interactions by alternative splicing and heparan sulfates, and their intracellular signaling machineries. In particular, we review structural insights on complexes of LAR-RPTPs with their various ligands. These studies lend support to general molecular mechanisms underlying LAR-RPTP-mediated synaptic adhesion and signaling pathways.
Full Text
http://www.sciencedirect.com/science/article/pii/S1937644816000034
DOI
10.1016/bs.ircmb.2016.01.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Um, Ji Won(엄지원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146507
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