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Can Hypertrophy of the Contralateral Testis Predict the Absence of a Viable Testis in Infancy with Cryptorchidism: A Prospective Analysis

 Hee Seo Son  ;  Yong Seung Lee  ;  Young Jae Im  ;  Sang Woon Kim  ;  Byung Hoon Chi  ;  Sang Won Han 
 PLoS One, Vol.11(3) : e0151528, 2016 
Journal Title
 PLoS One 
Issue Date
Case-Control Studies ; Cryptorchidism/pathology* ; Humans ; Hypertrophy ; Infant ; Male ; Prospective Studies ; Sensitivity and Specificity ; Testis/anatomy & histology ; Testis/growth & development* ; Testis/pathology* ; Testis/surgery
This prospective study aimed to evaluate whether Contralateral compensatory testicular hypertrophy (CTH) is valid as a predictive tool for a non-viable testis in children aged between 6 and 18 months, and whether CTH is affected by mini-puberty. Seventy-two testes from 60 boys aged between 6 and 18 months were categorized into three groups: 24 testes contralateral to surgically removed non-viable testes (NVTs), 24 testes contralateral to surgically corrected undescended testes (UDTs), and 24 testes from a normal controls. Contralateral testicular length and volume were measured with ultrasonography and compared among the groups. Group 1 (NVT) had a significantly longer length and larger volume than group 2 (UDT). The length and volume of each group among three developmental periods (6-10, 10-14, and 14-18 months) were also analyzed. In the controls, the length was significantly larger at 6-10 months than at 10-14 months in accordance with previously reported changes in testicular size due to the effect of "mini-puberty." The volume of controls showed a similar pattern, though without statistical significance. However, this pattern was not observed in the NVT and UDT groups. A receiver operating curve revealed that a testicular length of 16.1 mm or a volume of 0.59 ml had the highest sensitivity and specificity for predicting NVTs. The CTH was also found to be valid as a predictive tool for a NVT in children of ages 6 to 18 months, as the effect of mini-puberty appeared to be absent in the NVT and UDT groups. However, the cut-off values were less than those of previous reports. The proper cut-off level according to the age and measurement method should be applied in this developmental period.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김상운(Kim, Sang Woon) ORCID logo https://orcid.org/0000-0002-5790-1948
손희서(Son, Hee Seo) ORCID logo https://orcid.org/0000-0001-7198-7816
이용승(Lee, Yong Seung) ORCID logo https://orcid.org/0000-0003-3778-9888
임영재(Im, Young Jae)
한상원(Han, Sang Won) ORCID logo https://orcid.org/0000-0003-0941-1300
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