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Low Mitochondrial DNA Copy Number is Associated With Adverse Clinical Outcomes in Peritoneal Dialysis Patients

Authors
 Chang-Yun Yoon  ;  Jung Tak Park  ;  Youn Kyung Kee  ;  Seung Gyu Han  ;  In Mee Han  ;  Young Eun Kwon  ;  Kyoung Sook Park  ;  Mi Jung Lee  ;  Seung Hyeok Han  ;  Shin-Wook Kang  ;  Tae-Hyun Yoo 
Citation
 MEDICINE, Vol.95(7) : 2717, 2016 
Journal Title
 MEDICINE 
ISSN
 0025-7974 
Issue Date
2016
MeSH
Age Factors ; Aged ; Biomarkers ; Body Mass Index ; Female ; Humans ; Kidney Failure, Chronic/mortality* ; Kidney Failure, Chronic/therapy* ; Male ; Middle Aged ; Nutrition Assessment* ; Nutritional Status* ; Proportional Hazards Models ; Prospective Studies ; Protein-Energy Malnutrition/mortality ; Regression Analysis ; Renal Dialysis/statistics & numerical data* ; Risk Factors ; Sex Factors ; Survival Analysis
Abstract
Mitochondrial dysfunction may play an important role in abnormal glucose metabolism and systemic inflammation. We aimed to investigate the relationship between mitochondrial DNA (mtDNA) copy number and clinical outcomes in peritoneal dialysis (PD) patients. We recruited 120 prevalent PD patients and determined mtDNA copy number by PCR. Primary outcome was all-cause mortality, whereas secondary outcomes included cardiovascular events, technical PD failure, and incident malignancy. Cox proportional hazards analysis determined the independent association of mtDNA copy number with outcomes. The mean patient age was 52.3 years; 42.5% were men. The mean log mtDNA copy number was 3.30 ± 0.50. During a follow-up period of 35.4 ± 19.3 months, all-cause mortality and secondary outcomes were observed in 20.0% and 59.2% of patients, respectively. Secondary outcomes were significantly lower in the highest mtDNA copy number group than in the lower groups. In multiple Cox analysis, the mtDNA copy number was not associated with all-cause mortality (lower two vs highest tertile: hazard ratio [HR] = 1.208, 95% confidence interval [CI] = 0.477-3.061). However, the highest tertile group was significantly associated with lower incidences of secondary outcomes (lower two vs highest tertile: HR [95% CI] = 0.494 [0.277-0.882]) after adjusting for confounding factors. The decreased mtDNA copy number was significantly associated with adverse clinical outcomes in PD patients.
Files in This Item:
T201600509.pdf Download
DOI
10.1097/MD.0000000000002717
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kwon, Young Eun(권영은)
Kee, Youn Kyung(기연경)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Yoon, Chang Yun(윤창연)
Han, Seung Gyu(한승규)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
Han, In Mee(한인미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146437
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