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Noninvasive Prediction of Erosive Esophagitis Using a Controlled Attenuation Parameter (CAP)-Based Risk Estimation Model.

Authors
 Hyunsoo Chung  ;  Young Eun Chon  ;  Seung Up Kim  ;  Sang Kil Lee  ;  Kyu Sik Jung  ;  Kwang-Hyub Han  ;  Chae Yoon Chon 
Citation
 Digestive Diseases and Sciences, Vol.61(2) : 507-516, 2016 
Journal Title
 Digestive Diseases and Sciences 
ISSN
 0163-2116 
Issue Date
2016
MeSH
Adult ; Cohort Studies ; Esophagitis/complications* ; Esophagitis/diagnosis* ; Fatty Liver/complications* ; Fatty Liver/diagnosis* ; Female ; Humans ; Male ; Middle Aged ; Models, Biological* ; Obesity, Abdominal/complications ; Risk Factors
Keywords
Controlled attenuation parameter ; Erosive esophagitis ; Fatty liver ; GERD
Abstract
BACKGROUND: Erosive esophagitis and fatty liver share obesity and visceral fat as common critical pathogenesis. However, the relationship between the amount of hepatic fat and the severity of erosive esophagitis was not well investigated, and there is no risk estimation model for erosive esophagitis. AIM: To evaluate the relationship between the amount of hepatic fat and the severity of erosive esophagitis and then develop a risk estimation model for erosive esophagitis. METHODS: We enrolled 1045 consecutive participants (training cohort, n = 705; validation cohort, n = 340) who underwent esophagogastroduodenoscopy and CAP. The relationship between severity of fatty liver and erosive esophagitis was investigated, and independent predictors for erosive esophagitis that have been investigated through logistic regression analyses were used as components for establishing a risk estimation model. RESULTS: The prevalence of erosive gastritis was 10.7 %, and the severity of erosive esophagitis was positively correlated with the degree of hepatic fatty accumulation (P < 0.05). A CAP-based risk estimation model for erosive esophagitis using CAP, Body mass index, and significant alcohol Drinking as constituent variables was established and was dubbed the CBD score (AUROC = 0.819, range 0-11). The high-risk group (CBD score ≥3) showed significantly higher risk of having erosive esophagitis than the low-risk group (CBD score <3) (24.1 vs. 2.7 %, respectively; P < 0.001). The diagnostic accuracy of CBD score was maintained in the validation cohort (AUROC = 0.848). CONCLUSION: The severity of erosive esophagitis was positively correlated with the degree of hepatic fatty accumulation, and the CBD score might be a simple CAP-based risk model for predicting erosive esophagitis.
Full Text
http://link.springer.com/article/10.1007/s10620-015-3902-7
DOI
10.1007/s10620-015-3902-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김승업(Kim, Seung Up) ORCID logo https://orcid.org/0000-0002-9658-8050
이상길(Lee, Sang Kil) ORCID logo https://orcid.org/0000-0002-0721-0364
전영은(Chon, Young Eun)
전재윤(Chon, Chae Yoon)
정규식(Jung, Kyu Sik)
정현수(Chung, Hyun Soo)
한광협(Han, Kwang-Hyub) ORCID logo https://orcid.org/0000-0003-3960-6539
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146427
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