Cited 13 times in
Association of ISMav6 with the Pattern of Antibiotic Resistance in Korean Mycobacterium avium Clinical Isolates but No Relevance between Their Genotypes and Clinical Features
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2017-02-24T03:38:55Z | - |
dc.date.available | 2017-02-24T03:38:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146402 | - |
dc.description.abstract | The aim of this study was to genetically characterize clinical isolates from patients diagnosed with Mycobacterium avium lung disease and to investigate the clinical significance. Multi-locus sequencing analysis (MLSA) and pattern of insertion sequence analysis of M. avium isolates from 92 Korean patients revealed that all isolates were M. avium subspecies hominissuis. In hsp65 sequevar analysis, codes 2, 15, and 16 were most frequently found (88/92) with similar proportions among cases additionally two isolates belonging to code N2 and an unreported code were identified, respectively. In insertion element analysis, all isolates were IS1311 positive and IS900 negative. Four of the M. avium subsp. hominissuis isolates did not harbor IS1245 and 1 of the M. avium isolates intriguingly harbored DT1, which is thought to be a M. intracellulare-specific element. M. avium subsp. hominissuis harboring ISMav6 is prevalent in Korea. No significant association between clinical manifestation and treatment response has been found in patients with the hsp65 code type and ISMav6, indicating that no specific strain/genotype among M. avium subsp. hominissuis organisms was a major source of M. avium lung disease. Interestingly, the presence of ISMav6 was correlated with greater resistance to moxifloxacin. Conclusively, the genotype of Korean M. avium subsp. hominissuis isolates is not a disease determinant responsible for lung disease and specific virulent factors of M. avium subsp. hominissuis need to be investigated further. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e0148917 | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | DNA Transposable Elements/genetics* | - |
dc.subject.MESH | Drug Resistance, Bacterial/genetics | - |
dc.subject.MESH | Genetic Association Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Multilocus Sequence Typing | - |
dc.subject.MESH | Mycobacterium avium Complex/drug effects* | - |
dc.subject.MESH | Mycobacterium avium Complex/genetics | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection/epidemiology | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection/microbiology* | - |
dc.subject.MESH | Phylogeny | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Association of ISMav6 with the Pattern of Antibiotic Resistance in Korean Mycobacterium avium Clinical Isolates but No Relevance between Their Genotypes and Clinical Features | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Su-Young Kim | - |
dc.contributor.googleauthor | Byeong-Ho Jeong | - |
dc.contributor.googleauthor | Hye Yun Park | - |
dc.contributor.googleauthor | Kyeongman Jeon | - |
dc.contributor.googleauthor | Seung Jung Han | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Won-Jung Koh | - |
dc.identifier.doi | 10.1371/journal.pone.0148917 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 26859598 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e0148917 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(2) : e0148917, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47910 | - |
dc.type.rims | ART | - |
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