Cited 10 times in
Bone Regenerative Efficacy of Limited-Dose Escherichia Coli-Derived rhBMP-2 With Biphasic Calcium Phosphate Carrier in Rabbit Calvarial Defect Model.
DC Field | Value | Language |
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dc.contributor.author | 유훈 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2017-02-24T03:25:53Z | - |
dc.date.available | 2017-02-24T03:25:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1056-6163 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146342 | - |
dc.description.abstract | PURPOSE: The aim of this study was to characterize the healing in rabbit calvarial bone defects after delivery of limited-dose (1.5 μg) Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), and evaluate biphasic calcium phosphate (BCP) as a carrier. MATERIALS AND METHODS: Four 8-mm diameter circular calvarial bone defects were made in 16 rabbits and filled with one of the following: (1) nothing, (2) BCP alone, (3) ErhBMP-2-loaded absorbable collagen sponge (ACS), or (4) ErhBMP-2-loaded BCP. The animals were allowed to heal for either 2 or 8 weeks and were evaluated in clinical, microcomputed tomographic, histological, and histomorphometric analyses. RESULTS: Microcomputed tomography revealed extensive new bone formation in both of the limited-dose ErhBMP-2-loaded groups. However, bony collapse of the upper defect borders was found in the ErhBMP-2-loaded ACS group. Histomorphometric examination revealed significantly greater new bone formation at 8 weeks than at 2 weeks in all 4 groups (P < 0.05). Both new bone formation and the size of the augmented area differed significantly between the ErhBMP-2-loaded BCP group (6.88 ± 0.74 and 19.62 ± 0.77) and the ErhBMP-2-loaded ACS group (3.04 ± 0.27 and 5.41 ± 0.43) at 8 weeks of healing. CONCLUSION: ErhBMP-2 promotes bone regeneration in rabbit calvarial defects, even at a limited dose (1.5 μg). The results of this study suggest that BCP is the more efficient carrier for this protein than ACS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 16~23 | - |
dc.language | English | - |
dc.publisher | Williams & Wilkins | - |
dc.relation.isPartOf | IMPLANT DENTISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/therapeutic use* | - |
dc.subject.MESH | Bone Regeneration/drug effects* | - |
dc.subject.MESH | Escherichia coli/metabolism | - |
dc.subject.MESH | Hydroxyapatites/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Recombinant Proteins/therapeutic use | - |
dc.subject.MESH | Skull/growth & development | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.title | Bone Regenerative Efficacy of Limited-Dose Escherichia Coli-Derived rhBMP-2 With Biphasic Calcium Phosphate Carrier in Rabbit Calvarial Defect Model. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Periodontology | - |
dc.contributor.googleauthor | Hoon You | - |
dc.contributor.googleauthor | So-Ra Yoon | - |
dc.contributor.googleauthor | Hyun-Chang Lim | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.identifier.doi | 10.1097/ID.0000000000000364 | - |
dc.contributor.localId | A04612 | - |
dc.contributor.localId | A03185 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01041 | - |
dc.identifier.eissn | 1538-2982 | - |
dc.identifier.pmid | 26606286 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00008505-201602000-00004&LSLINK=80&D=ovft | - |
dc.subject.keyword | biphasic calcium phosphate | - |
dc.subject.keyword | bone morphogenetic protein 2 | - |
dc.subject.keyword | bone regeneration | - |
dc.subject.keyword | bone substitutes | - |
dc.subject.keyword | rabbit calvaria | - |
dc.contributor.alternativeName | You, Hoon | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | You, Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 16 | - |
dc.citation.endPage | 23 | - |
dc.identifier.bibliographicCitation | IMPLANT DENTISTRY, Vol.25(1) : 16-23, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47851 | - |
dc.type.rims | ART | - |
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