176 192

Cited 4 times in

Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

Authors
 Sung Woo Cho  ;  Byung Gyu Kim  ;  Byung Ok Kim  ;  Young Sup Byun  ;  Choong Won Goh  ;  Kun Joo Rhee  ;  Hyuck Moon Kwon  ;  Byoung Kwon Lee 
Citation
 ARQUIVOS BRASILEIROS DE CARDIOLOGIA, Vol.106(1) : 56-61, 2016 
Journal Title
 ARQUIVOS BRASILEIROS DE CARDIOLOGIA 
ISSN
 0066-782X 
Issue Date
2016
MeSH
Aged ; Biomarkers/blood ; Blood Glucose/analysis* ; Blood Sedimentation ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Cholesterol, HDL/blood* ; Coronary Disease/blood* ; Coronary Disease/diagnosis ; Coronary Disease/etiology ; Female ; Fibrinogen/analysis* ; Glycated Hemoglobin A/analysis* ; Glycemic Index ; Hemorheology ; Humans ; Male ; Middle Aged ; Outpatients ; Predictive Value of Tests ; Reproducibility of Results ; Risk Factors ; Statistics, Nonparametric
Keywords
Atherosclerosis ; Coronary Artery Disease ; Blood Sedimentation ; Fibrinogen ; Cardiovascular Diseases / adverse events
Abstract
BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. METHODS: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. RESULTS: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. CONCLUSION: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.
Files in This Item:
T201600194.pdf Download
DOI
10.5935/abc.20150146
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146311
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links