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Impact of smoking on neurodegeneration and cerebrovascular disease markers in cognitively normal men

Authors
 H. Cho  ;  C. Kim  ;  H. J. Kim  ;  B.S. Ye  ;  Y. J. Kim  ;  N.-Y. Jung  ;  T. O. Son  ;  E. B. Cho  ;  H. Jang  ;  J. Lee  ;  M. Kang  ;  H.-Y. Shin  ;  S. Jeon  ;  J.-M. Lee  ;  S. T. Kim  ;  Y.-C. Choi  ;  D.L. Na  ;  S. W. Seo 
Citation
 EUROPEAN JOURNAL OF NEUROLOGY, Vol.23(1) : 110-119, 2016 
Journal Title
 EUROPEAN JOURNAL OF NEUROLOGY 
ISSN
 1351-5101 
Issue Date
2016
MeSH
Aged ; Biomarkers ; Cerebral Cortex/pathology* ; Cerebrovascular Disorders/chemically induced* ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurodegenerative Diseases/chemically induced* ; Smoking/adverse effects* ; White Matter/pathology*
Keywords
Alzheimer's disease ; cerebrovascular disease ; cortical thickness ; dementia ; lacunes ; neurodegeneration ; smoking ; white matter hyperintensities
Abstract
BACKGROUND AND PURPOSE: Smoking is a major risk factor for cognitive decline and dementia. However, the exact pathobiology of smoking remains unknown. The effects of smoking on cortical thickness as a biomarker of neurodegeneration or white matter hyperintensities and lacunes as biomarkers of cerebrovascular burden were concurrently evaluated. METHODS: Our study included 977 cognitively normal men who visited a health promotion centre and underwent medical check-ups, including 3.0 T magnetic resonance imaging. Participants were categorized into never smoker, past smoker or current smoker groups and pack-years and the years of smoking cessation were used as continuous variables. RESULTS: The current smoker group exhibited cortical thinning in frontal and temporo-parietal regions compared with the never smoker group. These effects were particularly prominent in smokers with a high cumulative exposure to smoking in the current smoker group. However, there was no association between smoking and the severity of white matter hyperintensity or number of lacunes. CONCLUSION: Our findings indicate that smoking might impact on neurodegeneration rather than cerebrovascular burdens in cognitively normal men, suggesting that smoking might be an important modifiable risk factor for the development of Alzheimer's disease.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ene.12816/abstract
DOI
10.1111/ene.12816
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146298
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