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Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia.

Authors
 Jong Kyou Kwon  ;  Jang Hee Han  ;  Ho Chul Choi  ;  Dong Hyuk Kang  ;  Joo Yong Lee  ;  Jae Heon Kim  ;  Cheol Kyu Oh  ;  Young Deuk Choi  ;  Kang Su Cho 
Citation
 BJU International, Vol.117(2) : 316-332, 2016 
Journal Title
 BJU International 
ISSN
 1464-4096 
Issue Date
2016
MeSH
Humans ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/pathology* ; Male ; Middle Aged ; Organ Size ; Predictive Value of Tests ; Prostate/pathology* ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/pathology* ; Quality of Life ; Reproducibility of Results ; Urinary Bladder, Overactive/diagnosis ; Urinary Bladder, Overactive/pathology*
Keywords
benign prostatic hyperplasia ; lower urinary tract symptoms ; peripheral zone ; transrectal ultrasound
Abstract
OBJECTIVE: To evaluate the clinical impact of prostate peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter. PATIENTS AND METHODS: Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum urinary flow rate (Qmax ), and post-void residual urine volume (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), transition zone index (TZI), and PZT were measured by transrectal ultrasonography. Reliability analysis was also performed. RESULTS: In all, 1009 patients were enrolled for the analysis. The mean (sd) PZT was 11.10 (2.50) mm, and patients were classified into three groups PZT thickness groups; PZT <9.5 mm, ≥9.5 to <13 mm, and ≥13 mm. As the PZT became smaller, all urinary symptom scores including IPSS, quality of life (QoL), and OABSS significantly increased. Uroflowmetry variables, such as Qmax and PVR, also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that the PZT was independently associated with IPSS (P < 0.001), QoL (P = 0.003), OABSS (P = 0.001), and PVR (P = 0.001), but PZT influence on Qmax was only of borderline significance (P = 0.055). CONCLUSION: PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our present findings suggest that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/bju.13130/abstract
DOI
10.1111/bju.13130
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Joo Yong(이주용) ORCID logo https://orcid.org/0000-0002-3470-1767
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146256
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