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Pituitary 18F-FDG uptake correlates with serum TSH levels in subjects with diffuse thyroid 18F-FDG uptake

Other Titles
 양전자방출단층촬영술 시행 시 갑상샘의 미만성 FDG 섭취를 보이는 환자에서 우연적 뇌하수체의 FDG 섭취 정도와 혈중 갑상선 자극 호르몬 농도의 관계 파악 및 그에 따른 임상적 유용성 
Issue Date
Dept. of Medicine/석사
Purpose: The aim of this study was to evaluate the relationship among FDG uptake in the pituitary gland (FDGp), FDG uptake in the thyroid gland (FDGt), and serum thyroid-stimulating hormone (TSH) levels in patients with diffuse FDGt incidentally noted on positron emission tomography/computed tomography (PET/CT) scan.Materials and Methods: This retrospective study was approved by our institutional review board. We retrospectively reviewed FDG PET/CT scans of 2,945 subjects who underwent health screening. Of these, 44 subjects had diffuse FDGt and available thyroid function tests. FDGt and FDGp were correlated with serum TSH. FDGp in 44 paired control subjects without FDGt and 15 thyroid cancer patients undergoing thyroid hormone withdrawal were additionally measured, and compared with FDGp in the 44 subjects with FDGt divided into three groups according to serum TSH levels.Results: In the 44 subjects, there was a statistically significant (p=0.034) but weak correlation(r=0.320) between FDGt and TSH. On the other hand, a strong correlation was found between FDGp and TSH (p<0.001, r=0.618). As well, there were statistically significant differences in FDGp between the low, normal, and high TSH groups (p<0.001). FDGp in the paired control subjects was not different from that in the normal TSH group (p=0.384), and FDGp in the TSH-stimulated thyroid cancerpatients was not different from that in the high TSH group (p=0.463).Conclusion: In this study, we found a strong positive correlation between the degree of pituitary FDG uptake and serum TSH. It appears that FDG uptake in the pituitary gland holds an important clue to the functional status of the thyroid in subjects with diffuse thyroid FDG uptake.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 2. Thesis
Yonsei Authors
Jeong, Yong Hyu(정용휴) ORCID logo https://orcid.org/0000-0002-0198-0026
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