Cited 44 times in
Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species
DC Field | Value | Language |
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dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2017-01-19T13:02:47Z | - |
dc.date.available | 2017-01-19T13:02:47Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/145531 | - |
dc.description.abstract | The silver nanoparticle (AgNP) is a candidate for anticancer therapy because of its effects on cell survival and signaling. Although numerous reports are available regarding their effect on cell death, the effect of AgNPs on metabolism is not well understood. In this study, we investigated the effect of AgNPs on glucose metabolism in hepatoma cell lines. Lactate release from both HepG2 and Huh7 cells was reduced with 5 nm AgNPs as early as 1 hour after treatment, when cell death did not occur. Treatment with 5 nm AgNPs decreased glucose consumption in HepG2 cells but not in Huh7 cells. Treatment with 5 nm AgNPs reduced nuclear factor erythroid 2-like 2 expression in both cell types without affecting its activation at the early time points after AgNPs' treatment. Increased reactive oxygen species (ROS) production was detected 1 hour after 5 nm AgNPs' treatment, and lactate release was restored in the presence of an ROS scavenger. Our results suggest that 5 nm AgNPs affect glucose metabolism by producing ROS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 55~68 | - |
dc.language | English | - |
dc.publisher | DOVE Medical Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject.MESH | Antineoplastic Agents/chemistry | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/drug therapy | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Hep G2 Cells/drug effects | - |
dc.subject.MESH | Hep G2 Cells/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lactic Acid/metabolism | - |
dc.subject.MESH | Liver Neoplasms/drug therapy | - |
dc.subject.MESH | Liver Neoplasms/metabolism | - |
dc.subject.MESH | Metal Nanoparticles*/chemistry | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Silver/chemistry | - |
dc.subject.MESH | Silver/pharmacology* | - |
dc.title | Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species | - |
dc.type | Article | - |
dc.publisher.location | New Zealand | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Mi Jin Lee | - |
dc.contributor.googleauthor | Seung Jun Lee | - |
dc.contributor.googleauthor | Su Jin Yun | - |
dc.contributor.googleauthor | Ji-Young Jang | - |
dc.contributor.googleauthor | Hangoo Kang | - |
dc.contributor.googleauthor | Kyongmin Kim | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.contributor.googleauthor | Sun Park | - |
dc.identifier.doi | 10.2147/IJN.S94907 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01134 | - |
dc.identifier.eissn | 1178-2013 | - |
dc.identifier.pmid | 26730190 | - |
dc.subject.keyword | carbohydrate metabolism | - |
dc.subject.keyword | cytotoxicity | - |
dc.subject.keyword | lactic acid | - |
dc.subject.keyword | metal nanoparticles | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 68 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol.11 : 55-68, 2016 | - |
dc.date.modified | 2017-01-16 | - |
dc.identifier.rimsid | 47387 | - |
dc.type.rims | ART | - |
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