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Drug-eluting stents to prevent stent thrombosis and restenosis

Authors
 Eui Im  ;  Myeong-Ki Hong 
Citation
 EXPERT REVIEW OF CARDIOVASCULAR THERAPY, Vol.14(1) : 87-104, 2016 
Journal Title
 EXPERT REVIEW OF CARDIOVASCULAR THERAPY 
ISSN
 1477-9072 
Issue Date
2016
MeSH
Absorbable Implants ; Coated Materials, Biocompatible/pharmacology ; Coronary Restenosis*/etiology ; Coronary Restenosis*/prevention & control ; Drug-Eluting Stents*/adverse effects ; Drug-Eluting Stents*/standards ; Humans ; Immunosuppressive Agents/pharmacology ; Inventions ; Percutaneous Coronary Intervention/instrumentation* ; Polymers/pharmacology ; Postoperative Complications/prevention & control* ; Randomized Controlled Trials as Topic ; Sirolimus*/analogs & derivatives ; Sirolimus*/pharmacology ; Thrombosis*/etiology ; Thrombosis*/prevention & control
Keywords
drug-eluting stent ; stent restenosis ; stent thrombosis
Abstract
Although first-generation drug-eluting stents (DES) have significantly reduced the risk of in-stent restenosis, they have also increased the long-term risk of stent thrombosis. This safety concern directly triggered the development of new generation DES, with innovations in stent platforms, polymers, and anti-proliferative drugs. Stent platform materials have evolved from stainless steel to cobalt or platinum-chromium alloys with an improved strut design. Drug-carrying polymers have become biocompatible or biodegradable and even polymer-free DES were introduced. New limus-family drugs (such as everolimus, zotarolimus or biolimus) were adopted to enhance stent performances. As a result, these new DES demonstrated superior vascular healing responses on intracoronary imaging studies and lower stent thrombotic events in actual patients. Recently, fully-bioresorbable stents (scaffolds) have been introduced, and expanding their applications. In this article, the important concepts and clinical results of new generation DES and bioresorbable scaffolds are described.
Full Text
http://www.tandfonline.com/doi/full/10.1586/14779072.2016.1112267
DOI
10.1586/14779072.2016.1112267
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Im, Eui(임의) ORCID logo https://orcid.org/0000-0002-5333-7593
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/145509
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