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Effects of antirheumatic therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study

 Yong Beom Park  ;  Hyon K Choi  ;  Min Young Kim  ;  Won Ki Lee  ;  Jungsik Song  ;  Dong Kee Kim  ;  Soo Kon Lee 
 AMERICAN JOURNAL OF MEDICINE, Vol.113(3) : 188-193, 2002 
Journal Title
Issue Date
Adult ; Aged ; Analysis of Variance ; Antirheumatic Agents/administration & dosage* ; Arthritis, Rheumatoid/blood* ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy* ; C-Reactive Protein/analysis ; C-Reactive Protein/drug effects* ; Chi-Square Distribution ; Cholesterol, HDL/blood ; Cholesterol, HDL/drug effects ; Cholesterol, LDL/blood ; Cholesterol, LDL/drug effects ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Lipids/analysis ; Lipids/blood* ; Male ; Methotrexate/administration & dosage* ; Middle Aged ; Probability ; Prospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Triglycerides/analysis ; Triglycerides/blood
Rheumatoid arthritis ; InflammationHDL cholesterol ; Apolipoprotein A-I ; Atherosclerosis
Background: Patients with newly diagnosed rheumatoid arthritis have adverse serum lipid profiles. We sought to determine the effects of treating rheumatoid arthritis with antirheumatic drugs on these abnormal lipid levels. Subjects and methods: We studied 42 patients with newly diagnosed rheumatoid arthritis who had not been treated with corticosteroids or disease-modifying antirheumatic drugs. We measured serum lipid profiles at baseline and 1 year later, and determined whether there were differences in the changes in lipid levels between patients who met the American College of Rheumatology criteria for a 20% improvement in rheumatoid arthritis and those who did not. Results: Of the 42 patients, 27 (64%) met the criteria for a 20% improvement in rheumatoid arthritis during the 12-month study. In these patients, mean high-density lipoprotein (HDL) cholesterol levels increased by 21% (P <0.001), apolipoprotein A-I levels increased by 23% (P <0.001), and the ratio of low-density lipoprotein (LDL) cholesterol to HDL cholesterol level decreased by 13% (P = 0.10). There were significant between-group differences (responders–nonresponders) in the mean 12-month changes in HDL cholesterol levels (8.0 mg/dL; 95% confidence interval [CI]: 3 to 13 mg/dL; P = 0.002), apolipoprotein A-I levels (21 mg/dL; 95% CI: 8 to 33 mg/dL; P = 0.003), and the LDL cholesterol to HDL cholesterol ratio (–0.6; 95% CI: –0.1 to –1.0; P = 0.03), but not in LDL cholesterol, apolipoprotein B-100, or lipoprotein(a) levels. Conclusion: Active rheumatoid arthritis is associated with an adverse lipid profile that improves substantially following effective treatment of rheumatoid arthritis. This improvement may reduce the risk of cardiovascular disease.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ki(김동기)
Park, Yong Beom(박용범)
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Lee, Soo Kon(이수곤)
Lee, Won Ki(이원기)
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