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절제 불가능한 췌장암의 동시항암화학방사선요법

Other Titles
 Concurrent Chemoradiation for Unresectable Pancreatic Cancer 
Authors
 김용배  ;  성진실  ;  송시영  ;  박승우  ;  서창옥 
Citation
 Journal of the Korean Society for Therapeutic Radiology and Oncology (대한방사선종양학회지), Vol.20(4) : 328-333, 2002 
Journal Title
 Journal of the Korean Society for Therapeutic Radiology and Oncology (대한방사선종양학회지) 
ISSN
 1229-8719 
Issue Date
2002
Keywords
절제 불가능한 췌장암 ; 동시하암화학방사선요법 ; Gemcitabine ; Pacilitaxel
Abstract
Purpose: To analyze the treatment results of concurrent chemoradiation with oral 5-FU plus Gemcitabine or Paclitaxel for unresectable pancreatic cancer. Materials & Methods: The patients, who were diagnosed by imaging modalities or by explo-laparotomy, were treated with concurrent chemoradiation. Radiotherapy was delivered to primary tumor and regional lymph nodes, and the total dose was 45 ㏉. Patients received Gemcitabine 1,000 ㎎/㎡ or Paclitaxel 50 ㎎/㎡ weekly and oral 5-FU daily. The total number of cycles of chemotherapy ranged from 1 to 39 (median, 11 cycles). The follow-up period ranged from 6 to 36 months. Survival was analyzed using the Kaplan-Meier method. Results: Fifty-four patients between Jan. 1999 to Nov. 2001 were included in this study. Forty-two patients who completed the planned treatment were included in this analysis. The patients' age ranged from 37 to 73 years (median, 60 years) and the male to female ratio was 30:12. Treatment was interrupted for 12 patients due to; disease progression for 6 (50%), poor performance status for 4 (33.3%), intercurrent disease for 1 (8.3%), and refusal for 1 (8.3%). Response evaluation was possible for 40 patients. One patient gained complete remission and 24 patients gained partial remission, hence the response rate was 59%. The survival rates were 46.7% and 17.0% at 1 year and 2 years, respectively with a median survival time of 12 months. Patients treated with Paclitaxel showed superior outcomes compared to those patients treated with Gemcitabine, in terms of both response rate and survival rate although this difference was not statistically significant. Grade Ⅲ or Ⅳ hematologic toxicity was shown in 8 patients (19%), while grade Ⅲ or Ⅳ non-hematologic toxicity was shown in 5 patients (12%). Conclusion: Concurrent chemoradiation with oral 5-FU and Gemcitabine or Paclitaxel improves both the response rate and survival rate in patients with unresectable pancreatic cancer. A prospective study should be investigated in order to improve both the patient selection and the treatment outcome as well as to reduce the toxicity.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Suh, Chang Ok(서창옥)
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144705
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