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Effects of MK-801 and Morphine on Spinal C-Fos Expression during the Development of Neuropathic Pain
DC Field | Value | Language |
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dc.contributor.author | 박경아 | - |
dc.contributor.author | 이원택 | - |
dc.contributor.author | 이윤우 | - |
dc.date.accessioned | 2016-05-16T11:28:21Z | - |
dc.date.available | 2016-05-16T11:28:21Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144625 | - |
dc.description.abstract | The purpose of this study was to investigate the expression of c-fos in the spinal cord during the development of allodynia, induced by peripheral nerve injury. Following tight ligation of the left L5 and L6 spinal nerves of Sprague-Dawley rat, the lumbar spinal cord was postfixed following perfusion. Frontal frozen sections of 40 µm were immunostained according to the peroxidase-antiperoxidase method. The allodynic threshold was checked with 8 calibrated von Frey filaments. MK-801 (0.3 mg/kg), morphine (3 mg/kg) and saline (as a placebo) were administered subcutaneously 30 min before, and 24 and 48 hrs after surgery. The tactile threshold decreased below 3 g since 2 days after surgery in the saline and morphine groups, but delayed a little in the MK-801 group. In the superficial layer the number of Fos-like immunoreactive neurones (Fos-LI) peaked at 2 hours and decreased thereafter, and reached normal levels 24 hrs following operation, for all groups. In the deep layer they were biphasic, - peaking at 2 and 24 hrs - in the saline group, but were suppressed in the morphine and MK-801 groups until 7 days following operation. The above discrepancy between the number of Fos-LI and the allodynic threshold showed that central sensitizations are not critically involved in the development of nerve injury induced tactile allodynia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 370~376 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of MK-801 and Morphine on Spinal C-Fos Expression during the Development of Neuropathic Pain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Youn Woo Lee | - |
dc.contributor.googleauthor | Kyung Ah Park | - |
dc.contributor.googleauthor | Won Taek Lee | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01424 | - |
dc.contributor.localId | A03007 | - |
dc.contributor.localId | A03022 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.subject.keyword | Allodynia | - |
dc.subject.keyword | central sensitization | - |
dc.subject.keyword | spinal c-fos | - |
dc.subject.keyword | MK-801 | - |
dc.subject.keyword | morphine | - |
dc.contributor.alternativeName | Park, Kyung Ah | - |
dc.contributor.alternativeName | Lee, Won Taek | - |
dc.contributor.alternativeName | Lee, Youn Woo | - |
dc.contributor.affiliatedAuthor | Park, Kyung Ah | - |
dc.contributor.affiliatedAuthor | Lee, Won Taek | - |
dc.contributor.affiliatedAuthor | Lee, Youn Woo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 43 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 370 | - |
dc.citation.endPage | 376 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.43(3) : 370-376, 2002 | - |
dc.identifier.rimsid | 51310 | - |
dc.type.rims | ART | - |
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