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국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량

DC FieldValueLanguage
dc.contributor.author서창옥-
dc.date.accessioned2016-05-16T11:25:45Z-
dc.date.available2016-05-16T11:25:45Z-
dc.date.issued2002-
dc.identifier.issn1229-8719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144530-
dc.description.abstractPurpose: To determine the optimal radiation dose in a localized non-Hodgkin's lymphoma of the head and neck in the treatment setting for combined chemoradiotherapy. Materials and Methods: Fifty-three patients with stage Ⅰ and Ⅱ diffuse large cell non-Hodgkin's lymphoma of the head and neck, who were treated with combined chemoradiotherapy between 1985 and 1998 were retrospectively reviewed. The median age was 49 years, and the male-to-female ratio was approximately 1.6. Twenty-seven patients had stage Ⅰ disease and 26 had stage Ⅱ. Twenty-three patients had bulky tumors (≥5 ㎝) and 30 had non-bulky tumors (<5 ㎝). The primary tumors arose mainly from an extranodal organ (70%), most cases involving Waldeyer's ring (90%). All patients except one were initially treated with 3~6 cycles of chemotherapy, which was followed by radiotherapy. Radiation was delivered either to the primary tumor area alone (9%) or to the primary tumor area plus the bilateral neck nodes (91%) with a minimum dose of 30 ㏉ (range 30~60 ㏉). The failure patterns according to the radiation field were analyzed, and the relationship between the dose and the in-field recurrence was evaluated. Results: The 10-year overall survival and the 10-year disease free survival rates were similar at 75% and 76%, respectively. A complete response (CR) after chemotherapy was achieved in 44 patients (83%). Subsequent radiotherapy showed a CR in all patients. Twelve patients (23%) had a relapse of the lymphoma after the initial treatment. Two of these patients had a recurrence inside the radiation field. No clear dose response relationship was observed and no significant prognostic factors for the in-field recurrences were identified because of the small number of in-field recurrences. However, for patients with tumors <5 ㎝ in diameter, there were no in-field recurrences after a radiation dose 30 ㏉. The 2 in-field recurrences encountered occurred in patients with a tumor ≥5 ㎝. Conclusion: A dose of 30 ㏉ is sufficient for local control in patients with a non-bulky (<5 ㎝), localized, diffuse large cell non-Hodgkin's lymphoma when combined with chemotherapy. An additional boost dose in the primary site is recommended for patients with bulky tumors (≥5 ㎝).-
dc.description.statementOfResponsibilityopen-
dc.format.extent303~308-
dc.languageKorean-
dc.publisher대한방사선종양학회-
dc.relation.isPartOfJournal of the Korean Society for Therapeutic Radiology and Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량-
dc.title.alternativeThe Optimal Radiation Dose in Localized Head and Neck Diffuse Large Cell Lymphoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthor금웅섭-
dc.contributor.googleauthor서창옥-
dc.contributor.googleauthor김용배-
dc.contributor.googleauthor심수정-
dc.contributor.googleauthor표홍렬-
dc.contributor.googleauthor노재경-
dc.contributor.googleauthor정현철-
dc.contributor.googleauthor김귀언-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01919-
dc.relation.journalcodeJ01857-
dc.subject.keyword국한성 두경부 대세포성 림프종-
dc.subject.keyword항암화학방사선 병용요법-
dc.subject.keyword적정 방사선 조사선량-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.rights.accessRightsfree-
dc.citation.volume20-
dc.citation.number4-
dc.citation.startPage303-
dc.citation.endPage308-
dc.identifier.bibliographicCitationJournal of the Korean Society for Therapeutic Radiology and Oncology, Vol.20(4) : 303-308, 2002-
dc.identifier.rimsid50316-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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