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국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서창옥 | - |
dc.date.accessioned | 2016-05-16T11:25:45Z | - |
dc.date.available | 2016-05-16T11:25:45Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144530 | - |
dc.description.abstract | Purpose: To determine the optimal radiation dose in a localized non-Hodgkin's lymphoma of the head and neck in the treatment setting for combined chemoradiotherapy. Materials and Methods: Fifty-three patients with stage Ⅰ and Ⅱ diffuse large cell non-Hodgkin's lymphoma of the head and neck, who were treated with combined chemoradiotherapy between 1985 and 1998 were retrospectively reviewed. The median age was 49 years, and the male-to-female ratio was approximately 1.6. Twenty-seven patients had stage Ⅰ disease and 26 had stage Ⅱ. Twenty-three patients had bulky tumors (≥5 ㎝) and 30 had non-bulky tumors (<5 ㎝). The primary tumors arose mainly from an extranodal organ (70%), most cases involving Waldeyer's ring (90%). All patients except one were initially treated with 3~6 cycles of chemotherapy, which was followed by radiotherapy. Radiation was delivered either to the primary tumor area alone (9%) or to the primary tumor area plus the bilateral neck nodes (91%) with a minimum dose of 30 ㏉ (range 30~60 ㏉). The failure patterns according to the radiation field were analyzed, and the relationship between the dose and the in-field recurrence was evaluated. Results: The 10-year overall survival and the 10-year disease free survival rates were similar at 75% and 76%, respectively. A complete response (CR) after chemotherapy was achieved in 44 patients (83%). Subsequent radiotherapy showed a CR in all patients. Twelve patients (23%) had a relapse of the lymphoma after the initial treatment. Two of these patients had a recurrence inside the radiation field. No clear dose response relationship was observed and no significant prognostic factors for the in-field recurrences were identified because of the small number of in-field recurrences. However, for patients with tumors <5 ㎝ in diameter, there were no in-field recurrences after a radiation dose 30 ㏉. The 2 in-field recurrences encountered occurred in patients with a tumor ≥5 ㎝. Conclusion: A dose of 30 ㏉ is sufficient for local control in patients with a non-bulky (<5 ㎝), localized, diffuse large cell non-Hodgkin's lymphoma when combined with chemotherapy. An additional boost dose in the primary site is recommended for patients with bulky tumors (≥5 ㎝). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 303~308 | - |
dc.language | Korean | - |
dc.publisher | 대한방사선종양학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Therapeutic Radiology and Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량 | - |
dc.title.alternative | The Optimal Radiation Dose in Localized Head and Neck Diffuse Large Cell Lymphoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | 금웅섭 | - |
dc.contributor.googleauthor | 서창옥 | - |
dc.contributor.googleauthor | 김용배 | - |
dc.contributor.googleauthor | 심수정 | - |
dc.contributor.googleauthor | 표홍렬 | - |
dc.contributor.googleauthor | 노재경 | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.googleauthor | 김귀언 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01919 | - |
dc.relation.journalcode | J01857 | - |
dc.subject.keyword | 국한성 두경부 대세포성 림프종 | - |
dc.subject.keyword | 항암화학방사선 병용요법 | - |
dc.subject.keyword | 적정 방사선 조사선량 | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 303 | - |
dc.citation.endPage | 308 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.20(4) : 303-308, 2002 | - |
dc.identifier.rimsid | 50316 | - |
dc.type.rims | ART | - |
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