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Evaluation of Denka-Seiken Turbidimetric High-Sensitivity C-Reactive Protein Assay

Authors
 Hyun Ju Sung  ;  Jeong Ho Kim  ;  Rojin Park  ;  Kyung Ryul Lee  ;  Oh Hun Kwon 
Citation
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.40(8) : 840-845, 2002 
Journal Title
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE 
ISSN
 1434-6621 
Issue Date
2002
MeSH
MeSH terms ; C-Reactive Protein/analysis* ; Coronary Disease/blood ; Coronary Disease/diagnosis* ; Hemoglobins ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Nephelometry and Turbidimetry/instrumentation* ; Prognosis ; Reference Values ; Reproducibility of Results ; Sensitivity and Specificity ; Triglycerides
Keywords
C-reactive protein ; Turbidimetry
Abstract
C-reactive protein measured with a high sensitivity method (hsCRP) is an important prognostic indicator in patients with an acute coronary syndrome. We evaluated hsCRP measurement with regard to its precision, functional sensitivity, linearity, and interferences using Denka-Seiken CRP II Latex X2 turbidimetric method on two chemistry autoanalyzers: Olympus AU 640 and Hitachi 747. The coefficients of variation (CV) for within-run and between-run precision of hsCRP were satisfactory on both autoanalyzers. Functional sensitivities, expressed as concentrations associated with 10% total interassay CV, were 0.19 mg/l for the Hitachi 747 analyzer and 0.41 mg/l for the Olympus AU 640. The assay was linear up to 300 mg/l with a wide measuring range, which suggested the possibility of using this hsCRP measurement as an inflammation marker and as a risk marker for coronary heart disease (CHD). No significant interference was observed up to a triglyceride concentration of 34 mmol/l, and up to hemoglobin concentration of 4 g/l. The determination of hsCRP by turbidimetric method was satisfactory and acceptable for CHD risk assessment, as well as for use as a marker of inflammation.
Full Text
http://www.degruyter.com/view/j/cclm.2002.40.issue-8/cclm.2002.146/cclm.2002.146.xml
DOI
10.1515/CCLM.2002.146
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144489
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