217 229

Cited 16 times in

Familial correlation and heritability for cardiovascular risk factors

Authors
 Sun Ha Jee  ;  Il Suh  ;  So Young Won  ;  Mi Yang Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.43(2) : 160-164, 2002 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2002
MeSH
Adult ; Aged ; Aged, 80 and over ; Blood Pressure/genetics ; Body Mass Index ; Cardiovascular Diseases/genetics* ; Cholesterol/blood ; Female ; Genetic Predisposition to Disease/genetics* ; Humans ; Male ; Middle Aged ; Risk Factors
Keywords
Correlation ; heritability ; CVD risk factor
Abstract
The goal of this study was to describe the overall genetic contribution of phenotypic variation to cardiovascular disease. The study population included 7,589 family members of 1,891 families, derived from Korean Medical Insurance Corporation. The risk factors considered were systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and high serum cholesterol. The levels of cardiovascular disease risk factors were adjusted for age, gender, smoking and alcohol drinking. Heritability was estimated from the slope of the line linear regression of offspring on mid-parent. All risk factors showed positive familial correlations, and correlations were generally lower for spouses than for parent-offspring pairs. Spouse correlations showed increasing patterns with age. Parents-offspring correlations showed little variation with age, suggesting that the observed correlations with CVD risk factors were primarily due to genetic influences rather than environmental effects. Estimated heritabilities were 26% for BMI, 26% for high serum cholesterol, 19% for SBP, and 9% for DBP. These results highlight the importance of considering genetic factors in studies of cardiovascular risk factors.
Files in This Item:
T200210130.pdf Download
DOI
10.3349/ymj.2002.43.2.160
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144486
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse