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난치성 간질 환아의 성장상태, 칼슘 조절호르몬 농도 및 골밀도 소견

Other Titles
 Growth Status, Calcium Regulating Hormones and Bone Mineral Density in Children with Inttractable Epilepsy 
Authors
 조윤경  ;  박미정  ;  김흥동 
Citation
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.7(1) : 87-94, 2002 
Journal Title
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지) 
ISSN
 1226-2242 
Issue Date
2002
Keywords
Intractable epilepsy ; Growth ; Calcium-regulating hormones ; BMD
Abstract
Purpose : Abnormalities in calcium(Ca), vitamin D and bone mineral density(BMD) associated with antiepileptic drug(AED) are reported, but the results are inconsistent. In case of intractable epilepsy, poor growth and altered bone mineral metabolism may be prominent, possibly related to previous long-term use of multiple AED and poor activity. The aim of this study was to assess growth status, concentrations of calcium regulating hormones and BMD In children with intractable epilepsy. Methods : Sixty-six intractable epilepsy patients aged 0.8 to 14.7 years(mean±SD : 4.6±3.6 years) were included in the study. Height and weight were measured and then height SDS and weight SDS were calculated. Serum Ca, i-Ca, P, Mg, Zinc, osteocalcin, intact-PTH, 25-OHD, 1,25(OH)₂D were measured. BMD of the lumbar spine was measured by dual energy X-ray absorption. Results : Most of the patients showed normal height SDS and weight SDS. Percentage of severe short stature(height SDS <-2) was 1.5% and tall stature(height SDS >2) was 4.5%. Percentage of severe thin(weight SDS <-2) was 1.5% and obesity(weight SDS >2) was 6%. Duration of AED was not related to height SDS or weight SDS. Etiology of epilepsy and physical activity were not related to height SDS and weight SDS. Most of them had normal Ca, iCa, P, Mg, Zinc, intact-PTH, osteocalcin, 25-OHD and 1,25(OH)₂D concentrations. BMD was not related to the levels of Ca, i-Ca, P, Mg, intact-PTH, osteocalcin, 25-OHD, 1,25(OH)₂D. BMD was not related to the duration of AED. BMD positively correlated with age(r=0.75, P<0.01) and body weight(r=0.72, P<0.01). Conclusion : Most of the children with intractable epilepsy, who regularly visits epilepsy clinic, showed normal growth and normal bone mineral metabolism, but careful monitoring about growth and bone mineral metabolism is needed.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144415
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