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구강 전암병소에서 암발생 예측을 위한 p53과 p63의 발현 분석

Other Titles
 The Analysis of p53 and p63 Expression for the Risk Assessment of Malignant Transformation in Oral Precancerous Lesions 
Authors
 황진하  ;  윤정훈  ;  차인호  ;  홍준철  ;  김진 
Citation
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.26(4) : 315-327, 2002 
Journal Title
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지) 
ISSN
 1225-1577 
Issue Date
2002
Keywords
p53 ; p63 ; leukoplakia ; malignant transformation ; biomarker ; epithelial dysplasia
Abstract
Oral precancerous lesions have been considered as a target tissue for the early detection and chemoprevention study. The risk of malignant transformation in oral premalignant lesions should be accurately evaluated and properly treated to prevent from cancer development. Accordingly, the risk assessment and monitoring of chemoprevention effect are critically important to reduce cancer incidence. This study aimed to evaluate the usefulness of p53 and p63 expression as biomarkers for the risk assessment to malignant transformation in leukoplakia. This study used 21 cases of oral leukoplakia without malignant transformation and 7 cases with malignant transformation during more than 2 years follow-up period which were examined at the Department of Oral Pathology, Yonsei University College of Dentistry. Six cases of normal mucosa were used as a control. Monoclonal p53 and p63 antibodies were applied for immunohistochemical study. As results, p53 expression was shown in 6 of 21 cases(29%) of the leukoplakia without malignant transformation, and in 3 of 7 cases(43%) of the leukoplakia transformed to squamous cell carcinoma. Normal oral mucosa showed no detectable p53 expression. p63 expression was detected in 9 of 21 cases(42%) of the leukoplakia without malignant transformation, and 5 of 7 cases(71%) of the leukoplakia transformed to squamous cell carcinoma. In normal mucosa 2 of 6 cases(33%) showed p63 expression in basal and parabasal layer. These results suggest that p53 and p63 expression requires more intensive further study based on the longer period of follow-up and the larger scale-examination for the verification of the usefulness as a predictable biomarker assessing the risk of malignant transformation in oral precancerous lesions.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144405
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