0 254

Cited 0 times in

열성경련 플러스에서 SCN1B유전자의 돌연변이

Other Titles
 Mutations of SCN1B in Generalized Epilepsy with Febrile Seizures Plus(GEFS+). 
Authors
 노영래  ;  신미영  ;  김영훈  ;  고영선  ;  김진모  ;  김홍태  ;  김흥동  ;  황경태  ;  이권행 
Citation
 Journal of the Korean Child Neurology Society (대한소아신경학회지), Vol.10(2) : 219-225, 2002 
Journal Title
 Journal of the Korean Child Neurology Society (대한소아신경학회지) 
ISSN
 1226-6884 
Issue Date
2002
Keywords
Febrile seizure ; GEFS+ ; SCN1B ; Mutation
Abstract
Purpose : Febrile seizures affect 2-5% of all children younger than 6 years olf. A small proportion of children with febrile seizures later develop epilepsy. Generalized epilepsy with febrile seizures plus(GEFS+) is an important childhood genetic epilepsy syndrome with heterogeneous phenotypes, including febrile seizures(FS) and generalized epilepsies of variable severity. It was reported that the gene locus for GEFS+ exists in the chromosome 19q13.1, and has relationship with a 387 C→G mutation in the voltage-gated sodium channel β1 subunit(SCN1B) gene. This study is to determine whether there are mutations in children with GEFS+ and FS. Methods : Eighteen GEFS+ and thirteen FS patients were screened for mutations in the sodium channel beta-subunits SCN1B. The primer pairs used to amplify the exons of SCN1B are given in the supplementary data on the Neurology web site. All exons were amplified by PCR and PCR products were subsequently sequenced. Single-stranded conformation polymorphism(SSCP) was carried out using 8% polyacrylamide gel. Results : Twenty four patients(77%) were younger than 10 years old, three(10%) were between 10 and 14 years old, and four(13%) older than 14 years old. The ratio of female to male was 0.55:1.0 In phenotypes of GEFS+, fourteen patients(88%) had generalized tonic-clonic seizures, one patient(6%) myoclonic seizures and one patient(6%) atonic seizures. In EEG findings of GEFS+, eleven(78%) patients had normal findings, five(28%) patients generalized spike waves and two patients(11%) diffuse slowings. In sequencing and SSCP of PCR products, we could observe added C mutations between 224G and 225C of exon 3 in two unrelated patients with GEFS+. Conclusion : We proved the existence of a new mutation of SCN1B in two unrelated patients with GEFS+.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022737976
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144401
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links