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Self-expandable covered metallic esophageal stent impregnated with beta-emitting radionuclide

Authors
 Je Hwan Won  ;  Jong Doo Lee  ;  Hee Jung Wang  ;  Gui-Eon Kim  ;  Bong Wan Kim  ;  Hyunee Yim  ;  Sang Keon Han  ;  Chan H Park  ;  Chul Woo Joh  ;  Kyung-Hwa Kim  ;  Kyung Bae Park  ;  Kyong-Min Shin 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.53(4) : 1005-1013, 2002 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2002
MeSH
Animals ; Brachytherapy/methods* ; Dogs ; Epithelial Cells/pathology ; Epithelial Cells/radiation effects ; Esophageal Neoplasms/radiotherapy* ; Esophagus/pathology ; Esophagus/radiation effects ; Fluoroscopy ; Holmium/therapeutic use* ; Mucous Membrane/pathology ; Mucous Membrane/radiation effects ; Radioisotopes/therapeutic use* ; Radiometry
Keywords
Esophagus ; Intraluminal brachytherapy ; β-emitting radionuclide ; Metallic stent ; 166Ho
Abstract
PURPOSE: A specially designed self-expandable covered metallic stent impregnated with the beta-emitting radioisotope 166Ho (166Ho, energy: 1.85 and 1.76 MeV, T12: 26.8 h) was developed at our institute for the purpose of intraluminal palliative brachytherapy, as well as for treating malignant esophageal stricture and swallowing difficulty. The aim of this study was to evaluate the tissue response to brachytherapy and the safety of the radioactive metallic stent with regard to the normal canine esophagus before clinical application. METHODS AND MATERIALS: 166Ho was impregnated into the polyurethane membrane (50 micron thickness) covering the outer surface of a self-expandable metallic stent (diameter, 18 mm; length, 40 mm). Stents with radioactivity 4.0-7.8 mCi (Group A, n = 15), 1.0-1.8 mCi (Group B, n = 5), and 0.5-0.7 mCi (Group C, n = 5) were placed in the esophagi of 25 healthy beagle dogs, and the stents were tightly anchored surgically to prevent migration. The estimated radiation dose calculated by Monte Carlo simulation was 194-383 Gy in Group A, 48-90 Gy in Group B, and 23-32 Gy in Group C. The dogs were killed 8-12 weeks after insertion of the stents, and histologic examinations of the esophageal walls were performed. RESULTS: In Group A, 3 of 15 dogs died of wound infection, so specimens were obtained from only 12 dogs; all 12 cases showed esophageal stricture with mucosal ulceration. Microscopically, severe fibrosis and degeneration of the muscular propria were found in 3 dogs, complete fibrosis of the entire esophageal wall was found in 7 dogs, and esophageal fibrosis with radiation damage within periesophageal soft tissue was found in 2 dogs. However, esophageal perforation did not develop, despite extremely high radiation doses. In Group B, glandular atrophy and submucosal fibrosis were found, but the muscular layer was intact. In Group C, no histologic change was found in 3 dogs, but submucosal inflammation and glandular atrophy with intact mucosa were found in 2 dogs. CONCLUSIONS: A radioactive, self-expandable covered metallic stent can be used as an alternative therapeutic modality for the palliative treatment of malignant esophageal stricture.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301602028377
DOI
10.1016/S0360-3016(02)02837-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144361
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