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Atherosclerosis in rheumatoid arthritis - Morphologic evidence obtained by carotid ultrasound

 Yong-Beom Park  ;  Chul-Woo Ahn  ;  Hyon K. Choi  ;  Seung-Hoon Lee  ;  Byung-Hyun In  ;  Hyun-Chul Lee  ;  Chung-Mo Nam  ;  Soo-Kon Lee 
 Arthritis & Rheumatism, Vol.46(7) : 1714-1719, 2002 
Journal Title
 Arthritis & Rheumatism 
Issue Date
Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arteriosclerosis/pathology* ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology* ; Carotid Artery, Common/diagnostic imaging* ; Female ; Humans ; Middle Aged ; Prednisolone/pharmacology ; Prednisolone/therapeutic use ; Tunica Intima/diagnostic imaging ; Tunica Media/diagnostic imaging ; Ultrasonography
OBJECTIVE: Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients. METHODS: We used high-resolution B-mode ultrasound to compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women with RA and 53 controls matched by age, sex, and menopause status. No subject in either group had a history of atherosclerosis or its complications. We investigated the association between IMT and relevant clinical and therapeutic variables, including the impact of low-dose corticosteroid therapy (< or = 10 mg/day prednisolone). RESULTS: The mean +/- SD IMT of the left and right common carotid arteries in RA patients was significantly greater than that in controls (0.77 +/- 0.09 mm versus 0.68 +/- 0.14 mm; P < 0.001). Early RA (duration < or = 1 year) was associated with lesser IMT than was RA of longer duration (0.72 +/- 0.03 mm versus 0.78 +/- 0.01 mm; P < 0.04). Prednisolone use was not associated with increased IMT (0.78 +/- 0.02 mm in nonusers versus 0.76 +/- 0.01 mm in users; P = 0.38). CONCLUSION: Our data indicate that RA patients have an ultrasonic marker of early atherosclerosis consistent with an increased risk for atherosclerosis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Park, Yong Beom(박용범)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Soo Kon(이수곤)
Lee, Seung Hoon(이승훈)
Lee, Hyun Chul(이현철)
In, Byung Hyun(인병현)
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