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Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists

Authors
 Theodore P. Ciaraldi  ;  Bong Soo Cha  ;  Kyong Soo Park  ;  Leslie Carter  ;  Sunder R. Mudaliar  ;  Robert R. Henry 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.967 : 66-70, 2002 
Journal Title
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 
ISSN
 0077-8923 
Issue Date
2002
MeSH
Fatty Acids, Nonesterified/metabolism* ; Humans ; Muscle, Skeletal/metabolism* ; Oxidation-Reduction ; Receptors, Cytoplasmic and Nuclear/agonists* ; Receptors, Retinoic Acid/agonists* ; Transcription Factors/agonists*
Keywords
free fatty acids (FFA) ; metabolism ; oxidation ; muscle ; PPAR ; RXR ; lipid ; insulin
Abstract
Free fatty acid (FFA) oxidation in human skeletal muscle cells can be stimulated, both independently and in a synergistic manner, by agonists for PPARγ and RXR. Increased FFA disposal in muscle through augmented oxidation could reduce intramyocellular lipid accumulation. The abilities of such agents to improve glucose tolerance and insulin action may thus involve effects on both glucose and FFA metabolism.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2002.tb04264.x/abstract
DOI
10.1111/j.1749-6632.2002.tb04264.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144198
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