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The skin barrier state of aged hairless mice in a dry environment.

Authors
 E.H. Choi  ;  M.J. Kim  ;  S.K. Ahn  ;  W.S. Park  ;  E.D. Son  ;  G.W. Nam  ;  I. Chang  ;  S.H. Lee 
Citation
 BRITISH JOURNAL OF DERMATOLOGY, Vol.147(2) : 244-249, 2002 
Journal Title
BRITISH JOURNAL OF DERMATOLOGY
ISSN
 0007-0963 
Issue Date
2002
MeSH
Acetone ; Aging/physiology* ; Animals ; Environment* ; Epidermis/metabolism ; Epidermis/physiology* ; Epidermis/ultrastructure ; Lipid Metabolism ; Mice ; Mice, Nude ; Microscopy, Electron ; Time Factors ; Water Loss, Insensible*
Keywords
aged skin ; dry environment ; skin barrier
Abstract
Background Many elderly people have chronic xerosis, and frequently experience an exacerbation during winter.


Objectives To investigate the barrier state of aged murine skin with or without barrier disruption in a dry environment.


Methods Aged and young hairless mice were kept separately in dry and normal conditions for 9 days. Acetone treatment was used to perturb the skin barrier. Skin barrier function was measured as transepidermal water loss (TEWL), and morphological changes in the epidermis were studied by electron microscopy.


Results The baseline TEWL was not higher in the dry environment. The number of stratum corneum (SC) layers and the epidermal thickness of aged mice increased in the dry environment. The recovery rate of the aged skin barrier was neither accelerated nor delayed in the dry environment. In the normal environment, aged mice recovered more slowly than young mice. After barrier perturbation in the aged mice, changes in SC layers and in epidermal thickness were similar in the two environments. The secretion and number of lamellar bodies did not differ between the two environments.


Conclusions We confirmed that a dry environment induces epidermal proliferation and scaling in both aged and young mice. However, no remarkable difference was found in the skin barrier recovery of aged hairless mice in a dry environment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2133.2002.04918.x/abstract
DOI
10.1046/j.1365-2133.2002.04918.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144120
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