Cited 24 times in
Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이운규 | - |
dc.date.accessioned | 2016-05-16T11:14:23Z | - |
dc.date.available | 2016-05-16T11:14:23Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0300-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144104 | - |
dc.description.abstract | Tumor necrosis factor-alpha (TNF-α) is believed to play a central role in the pathogenesis of pneumoconiosis. TNF2, a polymorphism in the TNF-α gene promoter, has been associated with an increase in TNF-α production and airway inflammation. To investigate the frequency of TNF2 in patients who have coal workers' pneumoconiosis (CWP) and to determine whether it is associated with development of a large opacity in CWP, we investigated the expression of the TNF2 allele in 80 patients who had CWP and in 54 healthy controls using restriction fragment length polymorphism (RFLP). Compared to controls (10.2%), the frequency of the TNF2 allele was greater in the CWP patients (20.6%). Furthermore, the TNF2 allele was very common in patients who had a large opacity (28.2%) in comparison with 13.4% in those with simple CWP. From these data, we suggest that the TNF2 allele is associated with the development of a large opacity in CWP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 205~209 | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Coal | - |
dc.subject.MESH | Coal Mining* | - |
dc.subject.MESH | Dust | - |
dc.subject.MESH | Gene Frequency/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes/metabolism | - |
dc.subject.MESH | Occupational Diseases/genetics | - |
dc.subject.MESH | Pneumoconiosis/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic/genetics* | - |
dc.subject.MESH | Polymorphism, Restriction Fragment Length | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics* | - |
dc.subject.MESH | Smoking | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.title | Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Kyoung Ah Kim | - |
dc.contributor.googleauthor | Yong Yeun Cho | - |
dc.contributor.googleauthor | Jung Sik Cho | - |
dc.contributor.googleauthor | Ki Hwa Yang | - |
dc.contributor.googleauthor | Woon Kyu Lee | - |
dc.contributor.googleauthor | Kweon Haeng Lee | - |
dc.contributor.googleauthor | Yun Shin Kim | - |
dc.contributor.googleauthor | Young Lim | - |
dc.identifier.doi | 10.1023/A:1015914409661 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02996 | - |
dc.relation.journalcode | J02242 | - |
dc.identifier.eissn | 1573-4919 | - |
dc.identifier.pmid | 12162435 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A%3A1015914409661 | - |
dc.contributor.alternativeName | Lee, Woon Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Woon Kyu | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 234-235 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOCHEMISTRY, Vol.234-235(1-2) : 205-209, 2002 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.