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Viscoelastic protection from endothelial damage by air bubbles

DC Field Value Language
dc.contributor.author김응권-
dc.date.accessioned2016-05-16T11:14:10Z-
dc.date.available2016-05-16T11:14:10Z-
dc.date.issued2002-
dc.identifier.issn0886-3350-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144096-
dc.description.abstractPurpose: To determine whether viscoelastic materials effectively protect the corneal endothelium from air bubbles. Setting: Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. Methods: Human eye-bank and rabbit eyes had a standardized phacoemulsification procedure with or without viscoelastic material (Healon® [sodium hyaluronate 1.0%], Healon GV® [sodium hyaluronate 1.4%], or Viscoat® [chondroitin sulfate 4.0%−sodium hyaluronate 3.0%]). The integrity of the endothelium was examined after the procedure with F-actin staining and scanning electron microscopy. Rabbit eyes with and without viscoelastic material (Healon or Viscoat) had a standardized irrigation/aspiration (I/A) procedure. The mucinous layer of the endothelium was examined after the procedure with transmission electron microscopy. Results: In the phacoemulsification experiment without viscoelastic material, with Healon, and with Healon GV, the endothelium of human and rabbit corneas had many areas of cell loss in a pattern consistent with air-bubble damage. With Viscoat, endothelial cells remained intact. In the I/A experiment, the mucinous layer of Viscoat-exposed rabbit endothelium appeared thinner. In the same experiments without viscoelastic material or with Healon, the mucinous layer of the endothelium appeared normal. Conclusions: Viscoat effectively protected the endothelium from air-bubble damage. Viscoat appears to protect the endothelium by acting as a physical barrier. Its adherence is probably related to the way it interacts with the mucinous layer of the endothelium.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1047~1053-
dc.relation.isPartOfJOURNAL OF CATARACT AND REFRACTIVE SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActins/metabolism-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAir*-
dc.subject.MESHAnimals-
dc.subject.MESHChild-
dc.subject.MESHChondroitin/therapeutic use*-
dc.subject.MESHChondroitin Sulfates-
dc.subject.MESHDrug Combinations-
dc.subject.MESHEndothelium, Corneal/injuries*-
dc.subject.MESHEndothelium, Corneal/metabolism-
dc.subject.MESHEndothelium, Corneal/ultrastructure-
dc.subject.MESHEye Injuries/metabolism-
dc.subject.MESHEye Injuries/pathology-
dc.subject.MESHEye Injuries/prevention & control*-
dc.subject.MESHHumans-
dc.subject.MESHHyaluronic Acid/therapeutic use*-
dc.subject.MESHMicroscopy, Electron, Scanning-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhacoemulsification/methods-
dc.subject.MESHRabbits-
dc.titleViscoelastic protection from endothelial damage by air bubbles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorStephen M. Cristol-
dc.contributor.googleauthorShin J. Kang-
dc.contributor.googleauthorHenry F. Edelhauser-
dc.contributor.googleauthorHyung Lae Kim-
dc.contributor.googleauthorJae Bum Lee-
dc.identifier.doi10.1016/S0886-3350(01)01319-0-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.relation.journalcodeJ01299-
dc.identifier.eissn1873-4502-
dc.identifier.pmid12036653-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0886335001013190-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.rights.accessRightsnot free-
dc.citation.volume28-
dc.citation.number6-
dc.citation.startPage1047-
dc.citation.endPage1053-
dc.identifier.bibliographicCitationJOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol.28(6) : 1047-1053, 2002-
dc.identifier.rimsid55582-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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