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Effects of calcium phosphate ceramic bone graft materials on permanent teeth eruption in beagles.

Authors
 Jina Lee Linton  ;  Byung Wha Sohn  ;  Jong In Yook  ;  Racquel Z. Le Geros 
Citation
 CLEFT PALATE-CRANIOFACIAL JOURNAL, Vol.39(2) : 197-207, 2002 
Journal Title
 CLEFT PALATE-CRANIOFACIAL JOURNAL 
ISSN
 1055-6656 
Issue Date
2002
MeSH
Alginates/adverse effects ; Alginates/chemistry ; Alveolar Process/diagnostic imaging ; Alveolar Process/drug effects ; Alveolar Process/ultrastructure ; Alveoloplasty ; Animals ; Apatites/chemistry ; Apatites/therapeutic use ; Bicuspid/physiology ; Bicuspid/surgery ; Biocompatible Materials/chemistry ; Biocompatible Materials/therapeutic use ; Bone Substitutes/therapeutic use* ; Calcium Phosphates/chemistry ; Calcium Phosphates/therapeutic use* ; Ceramics/chemistry ; Ceramics/therapeutic use* ; Dental Sac/drug effects ; Dogs ; Follow-Up Studies ; Lactic Acid/chemistry ; Lactic Acid/therapeutic use ; Microscopy, Electron ; Odontogenesis/physiology ; Phagocytes/physiology ; Polyglycolic Acid/chemistry ; Polyglycolic Acid/therapeutic use ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers/chemistry ; Polymers/therapeutic use ; Radiography ; Spectrophotometry, Infrared ; Surface Properties ; Tooth Eruption/physiology* ; Tooth Extraction ; Tooth Socket/surgery ; Tooth, Deciduous/surgery
Keywords
alveolar bone graft ; calcium phosphate ceramics
Abstract
Objective: The aim of this study was to evaluate the use of calcium phosphate ceramic (CPC) materials as a potential alternative to autogenous secondary alveolar bone grafting in cleft lip and palate patients who are in mixed dentition. Sample: Four 12-week-old beagles and one 15-week-old beagle were used as subjects. Interventions: In each experimental beagle, the third and fourth deciduous premolars were extracted. The sockets were filled with four different CPC materials and sutured. Main Outcome Measure: The beagles were fed a soft diet for the following 8 weeks and then sacrificed for clinical, radiological, histological, transmission electron microscope (TEM), and infrared (IR) absorption analysis. Results: All four experimental graft materials allowed normal development and eruption of permanent premolars. In histological sections, small particles of biphasic calcium phosphate (BCP) and carbonate apatite (CO3-AP) were resorbed, and large particulate forms served as bone frames in cortical bones. Polymer coated with carbonate apatite (Poly/CO3-AP) did not cause inflammation but was pushed away to the soft tissue by erupting teeth. Alginate coated with carbonate apatite (alginate/CO3-AP) caused a severe inflammatory reaction to the point of destroying a part of the dental follicle and cortical bone. In TEM, resorption activity by phagocytic cells was observed only in CO3-AP. Direct bonding of CO3-AP to the bone was observed as the electron-dense interface between bone and CO3-AP. Conclusion: BCP and CO3-AP proved to be suitable as alveolar bone graft materials in areas where tooth eruption occurs. Of the four materials tested, CO3-AP produced the best results.
Full Text
http://www.cpcjournal.org/doi/abs/10.1597/1545-1569%282002%29039%3C0197%3AEOCPCB%3E2.0.CO%3B2
DOI
10.1597/1545-1569(2002)039<0197:EOCPCB>2.0.CO;2
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144091
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