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Intensity modulation technique using the complementary boost-fields for ethmoid sinus cancer

 Sang Wook Lee  ;  Gwi Eon Kim  ;  Chang Ok Suh  ;  Sung Sil Chu  ;  Kang Kyoo Lee  ;  Sun Rock Moon 
 CLINICAL ONCOLOGY, Vol.14(3) : 241-249, 2002 
Journal Title
Issue Date
Adult ; Aged ; Central Nervous System/radiation effects ; Ethmoid Sinus* ; Female ; Humans ; Male ; Middle Aged ; Paranasal Sinus Neoplasms/radiotherapy* ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Conformal* ; Visual Pathways/radiation effects
Ethmoid sinus carcinoma ; intensity-modulated radiation therapy ; radiotherapy technique ; three-dimensional conformal plans
Purpose: To explore a static intensity-modulated radiation therapy (IMRT) technique of a more homogeneous isodose distribution to an irregular-shaped tumour of the ethmoid sinus, with concomitantly sparing the adjacent critical normal organs including the orbit. Methods and Materials: We conducted a static IMRT technique adding 2 or smaller complementary boost-fields to the underdosed volume in the PTV, which resulted from complete blocking of the orbits in all coplanar or non-coplanar main ports of the standard 3-D CRT. The standard 3-D CRT plans (Plan A) and IMRT plans adding complementary boost fields (Plan B) were established for 10 patients with ethmoid sinus cancer. Two sets of different plans for each patient were compared using isodose distribution, dose statistics, and dose volume histogram (DVH) of the planning target volume (PTV) and also using dose statistics and DVH of the adjacent critical structures. Results: The IMRT plans adding 2 or more complementary boost-fields (Plan B) for each patient demonstrated better coverage and improved dose homogeneity of the PTV compared to the standard 3-D CRT plan (Plan A). Moreover, the radiation doses to adjacent normal tissue organs, such as the orbits, optic nerves, brain stem and optic chiasm were similarly spared in both plans. Conclusion: With concomitantly sparing the surrounding visual pathway structures, our IMRT technique using the complementary boost-fields was quantitatively better than current standard 3-D CRT technique with respect to the dose homogeneity within the PTV. Therefore, we believe that our technique, though still not ideal, is thorough enough to be used routinely in treatment of ethmoid sinus tumour.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Suh, Chang Ok(서창옥)
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