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In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea

Authors
 Dong Eun Yong  ;  Hee Jin Cheong  ;  Yang Soo Kim  ;  Yeon Joon Park  ;  Woo Joo Kim  ;  Jun Hee Woo  ;  Kyung Won Lee  ;  Moon Won Kang  ;  Youn Sung Choo 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.17(6) : 737-742, 2002 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2002
MeSH
Anti-Infective Agents/therapeutic use* ; Aza Compounds* ; Bacteria/drug effects* ; Ciprofloxacin/therapeutic use ; Fluoroquinolones* ; Gatifloxacin ; Gemifloxacin ; Haemophilus influenzae/drug effects ; Korea ; Levofloxacin ; Microbial Sensitivity Tests ; Moraxella/drug effects ; Moxifloxacin ; Naphthyridines/therapeutic use* ; Ofloxacin/therapeutic use ; Quinolines* ; Streptococcus pneumoniae/drug effects
Keywords
Fluoroquinolone ; Gemifloxacin ; Korea ; Streptococcus pneumoniae ; Haemophilus influenzae
Abstract
Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in vitro activities of gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used antimicrobial agents against 1,689 bacterial strains isolated at four Korean university hospitals during 1999-2000. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method of National Committee for Clinical Laboratory Standards. Gemifloxacin had the lowest MICs for the respiratory pathogens: 90% of Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were inhibited by 0.06, 0.03, and 0.03 mg/L, respectively. Gemifloxacin was more active than the other fluoroquinolones against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis. The MIC90s of gemifloxacin for Klebsiella oxytoca, Proteus vulgaris, and non-typhoidal Salmonella spp. were 0.25, 1.0, and 0.12 mg/L, respectively, while those for other Gram-negative bacilli were 4-64 mg/L. In conclusion, gemifloxacin was the most active among the comparative agents against Gram-positive species, including respiratory pathogens isolated in Korea.
Files in This Item:
T200207022.pdf Download
DOI
10.3346/jkms.2002.17.6.737
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144081
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