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척수손상 후 척수 내 GABA 체계의 손실이 중추 신경병증성 통증 유발의 원인이라는 행동학적 및 전기생리학적인 증거

Other Titles
 Involvement of ionotropic, rather than metabotropic, glutamate receptors in hyperexcitability of spinal dorsal horn neurons induced after spinal cord injury 
Authors
 곽영섭  ;  심범  ;  윤덕미  ;  남택상  ;  백광세  ;  임중우 
Citation
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.42(5) : 667-676, 2002 
Journal Title
 Journal of Korean Society of Anesthesiologist (대한마취과학회지) 
ISSN
 0302-5780 
Issue Date
2002
Keywords
Baclofen ; central pain ; GABA ; muscimol ; spinal cord injury
Abstract
Background: Allodynia, hyperalgesia, and spontaneous pain are symptoms characterized by chronic central pain which was frequently observed following a spinal cord injury (SCI). However, the underlying mechanism has not been fully understood. This study was conducted to investigate whether the loss of the GABAergic system in the spinal dorsal horn was involved in the development of central pain following a spinal cord injury. Methods: SCI was induced by a hemisection of the spinal cord at T13 in adult male Sprague-Dawley rats. Mechanical allodynia was tested by measuring paw withdrawal frequency in response to repeated applications of a von Frey hair to the plantar surface of the hind-paw. Single neuronal activity of the dorsal horn neurons (L4⁣L6) was recorded extracellularly using a carbon filament-filled glass microelectrode (2⁣4 MΩ). The drugs were intrathecally or topically administrated on the spinal surface for behavioral and electrophysiological experiments, respectively. Results: After a left spinal hemisection at T13, behavioral signs of mechanical allodynia developed on both hind-paws and responsiveness of spinal dorsal horn neurons increased on both sides of the spinal dorsal horn. GABA receptor agonists including GABAA and GABAB receptor subtypes suppressed mechanical allodynia on both sides of hind-paws and decreased responsiveness of spinal dorsal horn neurons on both sides of spinal cord. Conclusions: These results indicate that a loss of the GABAergic system within the spinal cord plays a key role on the development of central pain following a spinal cord injury
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144031
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