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이소플라본 섭취수준이 폐경기 여성의 혈청내 지질 패턴 및 골다공증 예방에 미치는 영향

Other Titles
 The Effect of Isoflavone on Serum Lipid Profiles and Bone Markers in Postmenopausal Women 
Authors
 이병석  ;  원형재  ;  이수경  ;  최윤  ;  윤선  ;  박기현  ;  조동제  ;  송찬호 
Citation
 Journal of Korean Society of Menopause (대한폐경학회지), Vol.8(1) : 59-67, 2002 
Journal Title
Journal of Korean Society of Menopause(대한폐경학회지)
ISSN
 1226-8704 
Issue Date
2002
Keywords
Isoflavone ; Lipid profile ; Bone marker ; Genistein ; Daidzein
Abstract
Objectives: We investigated the effect of isoflavone on postmenopausal symptoms, urinary isoflavone excretion, serum lipid profiles and bone markers to know the effect of isoflavone in postmenopausal women. Methods: 30 postmenopausal women took part in this study. They are divided into 3 subgroups according to the dose of isoflavone supplementation of 100 mg/day, 150 mg/day, and 200 mg/day. Isoflavones were consumed for 6 months. Fasting serum total cholesterol, triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) cholesterol lenel, lipoprotein-a, osteocalcin, and urinary deoxypyridinoline levels were measured initially and 6 months after each isoflavone supplementations. Result: The urinary isoflavone excretion was dose dependent in postmenopausal women and average 24-hr urinary recoveries of daidzein and genistein were approximately 15% and 7% respectively. isoflavone may not affect the serum total cholesterol, TG, LDL cholesterol, and lipoprotein-a levels. but isoflavone increase the HDL cholesterol level in each supplementation, especially increase significantly in 150 mg from 48.6±8.2 mg/dl to 57.3±9.9 mg/dl. Isoflavone decrease the bone marker, but it is not significant statistically. Conclusion: We suggest the isoflavone may beneficial effect on lipid profiles especially increasing serum HDL cholesterol level.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144030
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