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다운증후군과 동반된 백혈병 환자의 예후 및 임상분석

Other Titles
 The Clinical Features and Prognosis of Leukemia in Down Syndrome 
Authors
 최예나  ;  유철주  ;  전지현  ;  양창현  ;  오승환  ;  김길영 
Citation
 Korean Journal of Pediatric Hematology-Oncology (대한소아혈액종양학회지), Vol.9(2) : 186-193, 2002 
Journal Title
 Korean Journal of Pediatric Hematology-Oncology (대한소아혈액종양학회지) 
ISSN
 1225-6978 
Issue Date
2002
Keywords
Chromosome 21 ; Down syndrome ; Acute myeloid leukemia ; Acute lymphocytic leukemia ; Prognosis
Abstract
Purpose: There are several reports that the risk of development of leukemias is much higher in Down syndrome (DS) children than in non DS children. But there are a few reports about the clinical features of leukemia in Down syndrome and the prognosis in Korea. The object of this study is to evaluate clinical features, treatment results and the prognosis of leukemia of Down syndrome patients. Methods: We conducted retrospective reviews in 10 children with leukemia of Down syndrome who were admitted to the Department of Pediatrics in Yonsei University Hospital between March 1986 and December 2000. We analyzed the clinical features, laboratory findings and survival rates. Results: A male to female ratio was 1:1.25. Median age at diagnosis was 2 years 8 months. Initial symptoms were hepatosplenomegaly, petechiae, fever and upper respiratory infection symptoms. The number of patients by the type was as followed: acute myeloid leukemia (AML) 7 (70%), acute lymphocytic leukemia 2 (20%), acute mixed lineage leukemia 1 (10%). There were 4 cases of M7 subtype in AML. The median peripheral blood cell counts were as followed; leukocyte was 41,000/μL, hemoglobin was 8.7 g/dL, the platelet was 103,000/μL. The five years event free survival rate after diagnosis was 87.5% (7/8). The one patient relapsed and another one patient died of cardiac anomaly. Conclusion: There seemed to be several differences of clinical features between DS leukemia and non DS leukemia, especially prognosis. Multi-centered well organized study should be done to confirm our observation.
Files in This Item:
T200206438.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143984
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