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개의 동종 부분 간이식후 허혈-재관류손상에 대한 가돌리늄 클로라이드의 효과

Other Titles
 Ischemia-reperfusion Injury after Canine Liver Allo-transplantation The Effect of Gadolinium Chloride 
Authors
 정구용  ;  성순희  ;  정규영  ;  오수연  ;  김유선  ;  조백환  ;  최금자  ;  최용만 
Citation
 JOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.63(5) : 360-365, 2002 
Journal Title
JOURNAL OF THE KOREAN SURGICAL SOCIETY (대한외과학회지)
ISSN
 1226-0053 
Issue Date
2002
Keywords
Ischemia-Reperfusion injury ; Canine liver transplantation ; Gadolinium chloride
Abstract
Purpose: The effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/ reperfusion injury. In this study, the effect of Gadolinium, a synthetic Kupffer cell suppressor, on the reperfusion injury was examined using a canine partial liver transplant model.

Methods: About 70% of the liver was harvested and reimplanted in a mongrel recipient dog weighing 20∼25 ㎏. Gadolinium Chloride (10 ㎎/㎏) was infused via the cephalic vein 24 hour before harvesting the partial liver (Gadolinium group, n=5).
Serum Aspartate Aminotransferase (AST) Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH), and morphological grading of the graft were compared with the control group (n=5). Statistical analysis was done with an independent T-test.

Results: The total ischemic time was 4 hours and 27 minutes on average. One hour after reperfusion, there were no significant differences in the AST, ALP and LDH level, and the pathologic scores. At 48 hours after reperfusion, the AST (P=0.03) and LDH (P=0.05) levels were significantly lower in Gadolinium group.

Conclusion: Kupffer cell blockage using the Gadolinium chloride might be an effective way of reducing ischemia reperfusion injury. However, this effect was not evident in the early stages of reperfusion.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143965
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