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Serum Levels of Type 2 Chemokines in Lepromatous Leprosy Patients

Authors
 Wook Lew  ;  Koichiro Nakamura  ;  Yayoi Tada  ;  Ho Kwahck  ;  Soo Kyoung Chang  ;  Kunihiko Tamaki 
Citation
 IMMUNE NETWORK, Vol.2(4) : 223-226, 2002 
Journal Title
IMMUNE NETWORK
ISSN
 1598-2629 
Issue Date
2002
Keywords
Type 2 chemokine ; TARC ; MDC ; eotaxin ; lepromatous leprosy ; erythema nodosum leprosum
Abstract
BACKGROUND: The type 2 deviated immunological state is predominant in lepromatous leprosy. Erythema nodosum leprosum (ENL) is an immune-complex mediated reaction that typically occurs in lepromatous leprosy. To date, the serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-2 receptor, IL-10, IL-1beta, IL-1 receptor antagonist and monocyte chemoattractant protein-1 (MCP-1) were reported to be higher in lepromatous leprosy. TNF-alpha is also known to be higher in ENL, which is reduced after thalidomide treatment. However the serum type 2 chemokine levels in lepromatous leprosy patients have not been reported.0aMETHODS: The serum levels of the type 2 chemokines such as thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and eotaxin together with IL-12 and IL-10 in the sera from leprosy patients were detected using an enzyme-linked solvent assay (ELISA) method.0aRESULTS: The Serum TARC, MDC, eotaxin, IL-10 and IL-12 levels in lepromatous leprosy patients were not significantly different from the normal control levels. The serum levels were not significantly different between the paucibacillary group and multibacillary group. The serum TARC or MDC levels in the ENL patients were more reduced after a treatment containing thalidomide.0aCONCLUSION: The type 2 chemokines are not related to the severity of lepromatous leprosy. The larger reducing effect of the TARC or MDC levels in ENL patients by a treatment containing thalidomide suggests the potential role of these chemokines in the development of ENL and the therapeutic mechanism of thalidomide.
Files in This Item:
T200204984.pdf Download
DOI
10.4110/in.2002.2.4.223
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lew, Wook(유욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143775
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