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Clostridium difficile 감염 진단을 위한 C. difficile 정량배양 평가

Other Titles
 Evaluation of Quantitative culture of Clostridium difficile From Fecal Specimens for the Diagnosis of C. difficile-associated Disease 
 용동은  ;  이혁민  ;  류종하  ;  노경호  ;  김원호  ;  이경원  ;  정윤섭 
 Korean Journal of Clinical Microbiology (대한임상미생물학회지), Vol.5(2) : 124-128, 2002 
Journal Title
 Korean Journal of Clinical Microbiology (대한임상미생물학회지) 
Issue Date
Clostridium difficile ; C. difficile-associated diarrhea ; pseudomembranous colitis ; quantitative culture ; cytotoxin
Background: C. difficile-associated diarrhea (CDAD), the most frequently identified cause of nosocomial diarrhea, results from the overgrowth of cytotoxin (toxin B)-producing strains. The aim of this study was to evaluate the quantitative culture of Clostridium difficile to improve the laboratory diagnosis of CDAD. Methods: The quantitative culture and cytotoxin gene results were evaluated based on the findings of colonoscopy and/or histology of the biopsy specimens. Results: Among the 402 specimens with cytotoxin-positive isolates, 301 (74.9%) contained ≥106 CFU/mL of C. difficile. Nine (60%) of the 15 pseudomembranous colitis patients yielded ≥106 CFU/mL of toxigenic isolate. The proportion of cytotoxin gene-positive isolates was higher in the specimens with ≥106 CFU/mL of C. difficile than in those with 102-<103 CFU/mL (86.5% vs. 66.7%). Conclusions: Quantitative culture may aid in the interpretation of toxigenic C. difficile culture results, and reduce false positivity, thus avoiding unnecessary treatment.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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