Cited 81 times in
A protein sequence that can encode native structure by disfavoring alternate conformations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민구 | - |
dc.date.accessioned | 2016-05-16T10:57:06Z | - |
dc.date.available | 2016-05-16T10:57:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1072-8368 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143465 | - |
dc.description.abstract | The linear sequence of amino acids contains all the necessary information for a protein to fold into its unique three-dimensional structure. Native protein sequences are known to accomplish this by promoting the formation of stable, kinetically accessible structures. Here we describe a Pro residue in the center of the third transmembrane helix of the cystic fibrosis transmembrane conductance regulator that promotes folding by a distinct mechanism: disfavoring the formation of a misfolded structure. The generality of this mechanism is supported by genome-wide transmembrane sequence analyses. Furthermore, the results provide an explanation for the increased frequency of Pro residues in transmembrane alpha-helices. Incorporation by nature of such 'negative folding determinants', aimed at preventing the formation of off-pathway structures, represents an additional mechanism by which folding information is encoded within the evolved sequences of proteins. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 381~388 | - |
dc.relation.isPartOf | NATURE STRUCTURAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino AcidSequence | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Membrane/metabolism | - |
dc.subject.MESH | Circular Dichroism | - |
dc.subject.MESH | Computational Biology | - |
dc.subject.MESH | Cystic Fibrosis Transmembrane Conductance Regulator/chemistry* | - |
dc.subject.MESH | Cystic Fibrosis Transmembrane Conductance Regulator/genetics | - |
dc.subject.MESH | Cystic Fibrosis Transmembrane Conductance Regulator/metabolism* | - |
dc.subject.MESH | Genome | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liposomes/metabolism | - |
dc.subject.MESH | Micelles | - |
dc.subject.MESH | MolecularSequenceData | - |
dc.subject.MESH | Mutation/genetics | - |
dc.subject.MESH | Proline/genetics | - |
dc.subject.MESH | Proline/metabolism* | - |
dc.subject.MESH | ProteinFolding* | - |
dc.subject.MESH | ProteinStructure, Secondary | - |
dc.subject.MESH | Recombinant FusionProteins/chemistry | - |
dc.subject.MESH | Recombinant FusionProteins/genetics | - |
dc.subject.MESH | Recombinant FusionProteins/metabolism | - |
dc.subject.MESH | Spectroscopy, Fourier Transform Infrared | - |
dc.subject.MESH | Structure-Activity Relationship | - |
dc.subject.MESH | Thermodynamics | - |
dc.subject.MESH | Thiazoles/metabolism | - |
dc.title | A protein sequence that can encode native structure by disfavoring alternate conformations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | W. Christian Wigley | - |
dc.contributor.googleauthor | Michael J. Corboy | - |
dc.contributor.googleauthor | Todd D. Cutler | - |
dc.contributor.googleauthor | Patrick H. Thibodeau | - |
dc.contributor.googleauthor | Jorge Oldan | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Josep Rizo | - |
dc.contributor.googleauthor | John F. Hunt | - |
dc.contributor.googleauthor | Philip J. Thomas | - |
dc.identifier.doi | 10.1038/nsb784 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02781 | - |
dc.relation.journalcode | J02308 | - |
dc.identifier.pmid | 11938353 | - |
dc.identifier.url | http://www.nature.com/nsmb/journal/v9/n5/full/nsb784.html | - |
dc.contributor.alternativeName | Lee, Min Goo | - |
dc.contributor.affiliatedAuthor | Lee, Min Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | NATURE STRUCTURAL BIOLOGY , Vol.9(5) : 381-388, 2002 | - |
dc.identifier.rimsid | 53185 | - |
dc.type.rims | ART | - |
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