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전신마취 후 발생한 전율에 대한 DOXAPRAM의 용량에따른 치료효과 비료

Other Titles
 A Comparison of Effectiveness Correlated with Different Doses of Doxapram in the Treatment of Post-Anesthetic Shivering 
 임공빈  ;  이영복  ;  윤경봉  ;  채윤정  ;  이광호 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.37(5) : 662-667, 1999 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
Issue Date
Background: Although post-anesthetic shivering may be a temporary phenomenon, it leads to detrimental effects such as increased oxygen consumption, hypoxemia, and difficulty in monitoring. Doxapram is a relatively new treatment for post-anesthetic shivering, but there have been few reports about its minimum effective dose. The purpose of this study was to find the minimum dose of doxapram which would show an antishivering effect.

Methods: Sixty patients who had developed post-anesthetic shivering were divided into six groups of ten patients each. The groups were divided into a control group, which received normal saline, and the doxapram groups, which received five different doses of doxapram (0.15, 0.2, 0.5, 1.0, 1.5 mg/kg). The antishivering effect (2, 5, 10, 15 minutes after treatment), blood pressure, heart rate and temperature were compared among the groups.

Results: There was a significant difference in antishivering effect between the group which received normal saline and the groups which received doxapram; however, there was no significant difference within the groups which received doxapram.

Conclusions: We conclude that the dose of doxapram required to achieve an antishivering effect is much less than that currently in use.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
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