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Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2016-05-16T10:54:10Z | - |
dc.date.available | 2016-05-16T10:54:10Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143366 | - |
dc.description.abstract | Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects against experimentally induced gastrointestinal, hepatic and pancreatic damage. In the present study, we assessed the inhibitory effect of DA-9601 on tumor promotion, which is closely linked to inflammatory tissue damage. As an initial approach to evaluating the possible antitumor-promoting potential of DA-9601, its effects on TPA-induced ear edema were examined in female ICR mice. Pretreatment of the inner surface of the mouse ear with DA-9601 30 min prior to topical application of TPA inhibited ear edema at 5 hr. TPA-stimulated expression of epidermal COX-2 and iNOS was also mitigated by topical application of the same extract. Moreover, DA-9601 abrogated the TPA-mediated activation of NF-κB/Rel and AP-1 in mouse epidermis. Suppression of epidermal NF-κB by DA-9601 appeared to be mediated in part through inhibition of IκBα degradation, thereby blocking the nuclear translocation of p65, the functional subunit of NF-κB. DA-9601 also significantly suppressed TPA-induced ODC activity and papilloma formation in mouse skin. Taken together, these findings suggest that DA-9601 derived from A. asiatica possesses potential chemopreventive activities. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 456~462 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Hyo Joung Seo | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Seong Su Han | - |
dc.contributor.googleauthor | Won Yoon Chung | - |
dc.contributor.googleauthor | Mi Won Son | - |
dc.contributor.googleauthor | Won Bae Kim | - |
dc.contributor.googleauthor | Young Joon Surh | - |
dc.identifier.doi | 10.1002/ijc.10489 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03676 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ijc.10489/abstract | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 100 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 456 | - |
dc.citation.endPage | 462 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.100(4) : 456-462, 2002 | - |
dc.identifier.rimsid | 53109 | - |
dc.type.rims | ART | - |
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